PNAs conjugated to carrier peptides have been employed for the targeting of miRNA precursor, with the aim to develop molecules able to interfere in the pre-miRNA processing. The capability of the molecules to bind pre-miRNA has been tested in vitro by fluorescence assayes on Thiazole Orange labeled molecules and in vivo, in K562 cells, evaluating the amount of miRNA produced after treatment of ...

Charge transport is a fundamental and crucial process in organic electronics. Modern understanding of the transport has shown that, on single molecule level, this process can be described by through bond (TB) and through space (TS) models. The quantitative deciphering of the TB process has been established in recent years by the aid of scanning tunneling microscope (STM) technique and by making...

Conjugated rigid rod molecules are extensively studied for their optical and semiconducting properties. Since their size is suitable for the inclusion in SWNTs, they are optimal candidates molecules to obtain hybrid systems emitting in the visible spectral range [1]. Such hybrids systems are called peapods where the nanotube is the “pod” and the inserted molecule the “pea”. Successful encapsula...

NHL is the most common hematologic cancer in adults. Rituximab is the FDA approved treatment of relapsed or refractory low grade B-cell Non-Hodgkin Lymphoma (NHL). But patients eventually become resistant to rituximab. Since lymphocytes and lymphoma cells are highly radiosensitive, low grade NHL that has relapsed or refractory to standard therapy is treated by RIT in which a beta-emitting radio...

The conformational properties of conjugated heteroaromatic bipyridines, pyridyl-pyridiniums and bipyridinium have been investigated using density functional theory (DFT). The molecules studied were neutral 2,20-bipyridine (2,20-bpy), 2,30bipyridine (2,30-bpy) and 3,30-bipyridine (3,30-bpy) and the singly protonated 3-pyridyl-20-pyridinium (3-py-20-pyH) and 2pyridyl-20-pyridinium (2-py-20-pyH) a...