نتایج جستجو برای: conformational epitope

تعداد نتایج: 56057  

2017
Weicen Liu Jun Ren Jinlong Zhang Xiaohong Song Shuling Liu Xiangyang Chi Yi Chen Zhonghua Wen Jianmin Li Wei Chen

Yersinia pestis (Y. pestis) has caused an alarming number of deaths throughout recorded human history, and novel prophylactics and therapeutics are necessary given its potential as a bioweapon. Only one monoclonal antibody has been identified to date that provides complete protection against Y. pestis. Here, we describe a second novel murine monoclonal antibody (F2H5) that provided complete pro...

2013
Bifang He Canquan Mao Beibei Ru Hesong Han Peng Zhou Jian Huang

Metuximab is the generic name of Licartin, a new drug for radioimmunotherapy of hepatocellular carcinoma. Although it is known to be a mouse monoclonal antibody against CD147, the complete epitope mediating the binding of metuximab to CD147 remains unknown. We panned the Ph.D.-12 phage display peptide library against metuximab and got six mimotopes. The following bioinformatics analysis based o...

Journal: :Molecular immunology 2011
Andrew T Hutchinson Ralitza Alexova Vanessa Bockhorni Paul A Ramsland Darren R Jones Cameron V Jennings Kevin Broady Allen B Edmundson Robert L Raison

The murine mAb, K-1-21, recognizes a conformational epitope expressed on free Ig kappa light chains (FκLCs) and also on cell membrane-associated FκLCs found on kappa myeloma cells. This has led to the development of a chimeric version of K-1-21, MDX-1097, which is being assessed in a Phase II clinical trial for the treatment of multiple myeloma. The epitope recognized by K-1-21 is of particular...

2014
Konrad Krawczyk Xiaofeng Liu Terry Baker Jiye Shi Charlotte M. Deane

MOTIVATION Antibodies are currently the most important class of biopharmaceuticals. Development of such antibody-based drugs depends on costly and time-consuming screening campaigns. Computational techniques such as antibody-antigen docking hold the potential to facilitate the screening process by rapidly providing a list of initial poses that approximate the native complex. RESULTS We have d...

Journal: :International immunology 2001
E R Brandt P J Yarwood D J McMillan H Vohra B Currie L Mammo S Pruksakorn J Saour M F Good

Rheumatic fever (RF)/rheumatic heart disease (RHD) and post-streptococcal glomerulonephritis are thought to be autoimmune diseases, and follow group A streptococcal (GAS) infection. Different GAS M types have been associated with rheumatogenicity or nephritogenicity and categorized into either of two distinct classes (I or II) based on amino acid sequences present within the repeat region ('C' ...

2017
Long Zheng Peisheng Hu Brandon Wolfe Caryn Gonsalves Luqing Ren Leslie A Khawli Harvey R Kaslow Alan L Epstein

T cells expressing chimeric antigen receptors (CARs) recognizing CD19 epitopes have produced remarkable anti-tumor effects in patients with B-cell malignancies. However, cancer cells lacking recognized epitopes can emerge, leading to relapse and death. Thus, CAR T cells targeting different epitopes on different antigens could improve immunotherapy. The Lym-1 antibody targets a conformational ep...

Journal: :Journal of immunology 2011
Mi Li Alla Gustchina Jill Glesner Sabina Wünschmann Lisa D Vailes Martin D Chapman Anna Pomés Alexander Wlodawer

The crystal structure of a murine mAb, 4C3, that binds to the C-terminal lobe of the cockroach allergen Bla g 2 has been solved at 1.8 Å resolution. Binding of 4C3 involves different types of molecular interactions with its epitope compared with those with the mAb 7C11, which binds to the N-terminal lobe of Bla g 2. We found that the 4C3 surface epitope on Bla g 2 includes a carbohydrate moiety...

Journal: :The Journal of Experimental Medicine 1987
R W Eyre J R Stanley

Pemphigus foliaceus (PF) patients have antibodies against a tightly, but noncovalently bound complex of polypeptides, which consists of desmoglein I (DGI) and other, possibly desmosomal, proteins. Most PF antibodies bind a calcium-sensitive epitope on this complex and chelation of calcium destroys the reactivity of these sera with the complex, but not the complex itself. The PF sera that do bin...

Journal: :Virology 2009
Chao Bian Xiuqin Zhang Xingfeng Cai Linqi Zhang Zhiwei Chen Ye Zha Ying Xu Ke Xu Wei Lu Linchen Yan Jianwei Yuan Jiannan Feng Pei Hao Qidi Wang Guoping Zhao Gang Liu Xueliang Zhu Hao Shen Bojian Zheng Beifen Shen Bing Sun

The receptor-binding domain (RBD) on spike protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is the main region interacting with the viral receptor-ACE2 and is a useful target for induction of neutralizing antibodies against SARS-CoV infection. Here we generated two monoclonal antibodies (mAbs), targeting RBD, with marked virus neutralizing activity. The mAbs recogn...

2016
Julie C F Rappe Obdulio García-Nicolás Franziska Flückiger Barbara Thür Martin A Hofmann Artur Summerfield Nicolas Ruggli

Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus responsible for a widespread contagious disease of domestic pigs with high economic impact. Switzerland is one of the rare PRRSV-free countries in Europe, although sporadic outbreaks have occurred in the past. The PRRSV isolate IVI-1173 from the short outbreak in Switzerland in 2012 was entirely sequenced, and a funct...

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