Oxygen therapy is essential in all wards, emergency departments and operating theatres of hospitals at all levels, and oxygen is life-saving. In Papua New Guinea (PNG), an effective oxygen system that improved the detection and treatment of hypoxaemia in provincial and district hospitals reduced death rates from pneumonia in children by as much as 35%. The methods for providing oxygen in PNG ar...

Ageneral solution,basedontheseparationofvariablesmethod,for the thermal spreadingresistance incompound annular sectors, is presented. Results are given for three heat  ux distributions: inverse parabolic, uniform, and parabolic proŽ les. The general solution can be used to model any number of equally spaced heat sources on a compound or isotropic annulus. Graphical results are presented for a ...

A sparse crossbar (n,m)-concentrator is a bipartite graph with n source and m sink vertices, m ≤ n, in which there exists a matching between every m source vertices and the m sink vertices. In this paper, we investigate the structure, and the density of sparse crossbar (n,m)-concentrators among all 2 bipartite graphs. We establish that the density of sparse crossbar concentrators is bounded fro...

In this paper a two-level hierarchical model for the location of concentrators and routers in computers networks is presented. Given a set of candidate locations and the capacities of concentrators and routers the problem is to determine how many concentrators and routers should be used, where they should be located and which users to assign to each concentrator and which concentrators to alloc...

14 Abstract Osteoarthritis (OA) is the most common form of 15 chronic musculoskeletal disorders. A migratory stem cell pop16 ulation termed chondrogenic progenitor cells (CPC) with 17 in vitro chondrogenic potential was previously isolated from 18 OA cartilage. Since intracellular Ca signalling is an impor19 tant regulator of chondrogenesis, we aimed to provide a 20 detailed understanding of th...

Centromere protein A (CENP-A) is a homolog of histone H3 that epigenetically marks the heterochromatin of chromosomes. CENP-A is a critical component of the cell cycle machinery that is necessary for proper assembly of the mitotic spindle. However, the role of CENP-A in the heart and cardiac progenitor cells (CPCs) has not been previously studied. This study shows that CENP-A is expressed in CP...

RATIONALE Stem cell therapies to regenerate damaged cardiac tissue represent a novel approach to treat heart disease. However, the majority of adoptively transferred stem cells delivered to damaged myocardium do not survive long enough to impart protective benefits, resulting in modest functional improvements. Strategies to improve survival and proliferation of stem cells show promise for signi...

RATIONALE TBX1 encodes a T-box transcription factor implicated in DiGeorge syndrome, which affects the development of many organs, including the heart. Loss of Tbx1 results into hypoplasia of heart regions derived from the second heart field, a population of cardiac progenitors cells (CPCs). Thus, we hypothesized that Tbx1 is an important player in the biology of CPCs. OBJECTIVE We asked whet...

The myocardium is unable to regenerate itself after infarct, resulting in scarring and thinning of the heart wall. Our objective was to develop a patch to buttress and bypass the scarred area, while allowing regeneration by incorporated cardiac stem/progenitor cells (CPCs). Polycaprolactone (PCL) was fabricated as both sheets by solvent casting, and fibrous meshes by electrospinning, as potenti...