An analytical model is developed for a prismatic SMA beam with rectangular cross section subjected to alternating bending at temperature below the austenitic transformations. The loading path consists in loading-unloading cycle under and then reversed bending. Two opposite martensitic variants take place, whose volume fractions evolve linearly axial stress. Different Young’s moduli are taken ph...

Two different methods have been used to fatigue test four bone cements. Each method has been used previously, but the results have not been compared. The ISO 527-based method tests a minimum of 10 samples over a single stress range in tension only and uses Weibull analysis to calculate the median number of cycles to failure and the Weibull modulus. The ASTM F2118 test regime uses fewer specimen...

Large-scale proteomics often employs two orthogonal separation methods to fractionate complex peptide mixtures. Fractionation can involve ion exchange separation coupled to reversed-phase separation or, more recently, two reversed-phase separations performed at different pH values. When multidimensional separations are combined with tandem mass spectrometry for protein identification, the strat...

The mass spectrometric analysis of protein phosphorylation is still far from being routine, and the outcomes thereof are often unsatisfying. Apart from the inherent problem of substoichiometric phosphorylation, three arguments as to why phosphorylation analysis is so problematic are often quoted, including (a) increased hydrophilicity of the phosphopeptide with a concomitant loss during the loa...

Glutathione (GSH) is an abundant intracellular tripeptide that has been implicated as an important regulator of T cell proliferation. The effect of pharmacological regulators of GSH and other thiols on murine T cell signaling, proliferation, and intracellular thiol levels was examined. l-Buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, markedly reduced GSH levels and blocked T c...

Berberine was loaded in yeast cells of Saccharomyces cerevisiaeas a novel pharmaceutical carrier to improve the treatment ofmany diseases. The yeast-encapsulated active materialsshowedhigh stability and bioavailability due to the enhanced solubility and sustained releasing. In this study, different characteristics of prepared berberine loaded yeast cells (loading capacity, release kinetic order...

The present investigation presents a stochastic model for a flexible manufacturing system consisting of flexible machine, loading/unloading robot and an automated pallethandling device. We consider unreliable flexible manufacturing cell (FMC) wherein machine and robot operate under individual as well as common cause random failures. The pallethandling system is completely reliable. The pallet o...

BACKGROUND Small GTPases (guanosine triphosphate, GTP) are involved in many critical cellular processes, including inflammation, proliferation, and migration. GTP loading and isoprenylation are two important post-translational modifications of small GTPases, and are critical for their normal function. In this study, we investigated the role of post-translational modifications of small GTPases i...

Time reversal active sensing using Lamb waves is investigated for health monitoring of a composite structure. In the present work experiments were conducted on a glass/epoxy composite plates to study the time reversal behavior of A0 and S0 Lamb wave modes. PZT wafer sensors were surface bonded to the structure for generation and reception of the Lamb wave modes. Time reversal experiments were f...