نتایج جستجو برای: complementing group 1 xrcc1 gene

تعداد نتایج: 4202903  

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003
Xiao-Ou Shu Qiuyin Cai Yu-Tang Gao Wanqing Wen Fan Jin Wei Zheng

XRCC1 (X-ray repair cross-complementing group 1) is a base excision repair protein that plays a central role in the repair of DNA base damage and strand breaks. A common polymorphism (Arg-->Gln) at codon 399 of the XRCC1 gene has been previously linked to functional changes of the gene product and risk of cancers. We evaluated the association between XRCC1 Arg399Gln polymorphism and breast canc...

Bazrgar M, Fakhri M Gourabi H Hassani F Valojerdi MR Vazirinasab H Yazdi PE

Background: Chromosome abnormalities are associated with poor morphology and development in human preimplantation embryos, all together lead to poor outcomes. This study aimed to explore altered expression of DNA damage pathways in “poor morphological and development embryos with sever aneuploidies”. Materials and Methods: Surplus day-4 embryos of PGD cases were pooled in two groups: Poor progn...

2014
Li-Wen He Rong Shi Lei Jiang Ye Zeng Wen-Li Ma Jue-Yu Zhou

BACKGROUND Three extensively investigated polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) in the X-ray repair cross-complementing group 1 (XRCC1) gene have been implicated in risk for glioma. However, the results from different studies remain inconsistent. To clarify these conflicts, we performed a quantitative synthesis of the evidence to elucidate these associations in the Chinese populat...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Ya-Dong Wang Wen-Long Zhai Hai-Yu Wang Xiang-Qun Xia

BACKGROUND A number of studies have reported the association of X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism with susceptibility to hepatocellular carcinoma (HCC). However, the results were inconsistent and inconclusive. The aim of this study was to comprehensively explore the association of XRCC1 Arg399Gln variant with HCC risk. MATERIALS AND METHODS Systematic sea...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2013
Yan Pan Lei Zhao Xing-Miao Chen Yong Gu Jian-Gang Shen Lu-Ming Liu

The potential correlation of X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism with hepatocellular carcinoma (HCC) susceptibility is ambiguous. Taking account of inconsistent results of previous meta-analyses and new emerging literatures, we conducted a meta-analysis covering 15 case-control datasets to evaluate the relationship. Relevant studies from Medline, Embase and C...

2006
XIANGJUN ZHAI JIYONG LIU ZHIBIN HU SHUI WANG JIANWEI QING XUECHEN WANG GUANGFU JIN JUN GAO XINRU WANG

Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are two major base excision repair (BER) proteins and act cooperatively in the BER processes. Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Gln may alter their protein functions and BER activity, and were therefore hypothesized to be associated with breast cancer susceptibility. We examined the c...

2016
Liang Chen Mei-Mei Liu Hui Liu Dan Lu Xiao-Dan Zhao Xue-Jing Yang

Our study aimed to investigate the correlation between single nucleotide polymorphisms of ERCC1/XRCC1/XPA genes and postoperative chemotherapy efficacy and prognosis of endometrial carcinoma. Our study included 108 patients with endometrial carcinoma and 100 healthy participants. ERCC1 rs11615/XRCC1 rs25487/XPA rs1800975 gene polymorphisms were detected by polymerase chain reaction-restriction ...

Background: Gastric cancer is one of the most common malignancies in the world. It may result from a defect in the genes involved in DNA repair. One of the essential genes in the repair pathway is the XRCC1 gene that its polymorphisms in the human population play a role in gastric cancer susceptibility. The main purpose of this study was to investigate the association of 194C/T and 399G/A polym...

Journal: :Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2015
Pelin Mutlu Murad Mutlu Serap Yalcin Gozde Unsoy Atilay Yaylaci Guleser Saylam Istemihan Akin Hakan Korkmaz Ufuk Gunduz

PURPOSE X-ray repair cross-complementing (XRCC1) is one of the most important genes for the maintenance of genomic integrity and protection of cells from DNA damage. Although tobacco and alcohol consumption are the major risk factors for the development of head and neck squamous cell carcinoma (HNSCC), sequence variation in XRCC1 gene may alter HNSCC susceptibility. Reports on the relationship ...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Han-Lin Shuai Xin Luo Rui-Ling Yan Jian Li Dan-Liang Chen

BACKGROUND Functional single nucleotide polymorphisms of x-ray repair cross-complementing protein 1 (XRCC1) have been suspected to contribute to uterine cervical cancer risk for a long time; however, most previous case-control studies were small sized and biased. Additionally, recent studies suggested that XRCC1 polymorphisms could be a biomarker of response to platinum-based chemotherapy. ME...

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