نتایج جستجو برای: complement component c5a

تعداد نتایج: 681062  

Journal: :The Journal of clinical investigation 2006
Bart N Lambrecht

The anaphylatoxins complement component 3a and 5a (C3a and C5a, respectively) are classically seen as proinflammatory mediators of allergic asthma that recruit inflammatory cells, induce edema, and cause bronchoconstriction. A few years ago, controversy arose when it was shown that C5-deficient mice were more susceptible to experimental asthma compared with C5-sufficient mice. In a study by Köh...

2017
Catharina Busch Balasubramaniam Annamalai Khava Abdusalamova Nadine Reichhart Christian Huber Yuchen Lin Emeraldo A. H. Jo Peter F. Zipfel Christine Skerka Gerhild Wildner Maria Diedrichs-Möhring Bärbel Rohrer Olaf Strauß

PURPOSE The retinal pigment epithelium (RPE) is a main target for complement activation in age-related macular degeneration (AMD). The anaphylatoxins C3a and C5a have been thought to mostly play a role as chemoattractants for macrophages and immune cells; here, we explore whether they trigger RPE alterations. Specifically, we investigated the RPE as a potential immunoregulatory gate, allowing f...

2013
Kai Hoehlig Christian Maasch Nelli Shushakova Klaus Buchner Markus Huber-Lang Werner G Purschke Axel Vater Sven Klussmann

Complement factor C5a is a potent proinflammatory mediator that contributes to the pathogenesis of numerous inflammatory diseases. Here, we describe the discovery of NOX-D20, a PEGylated biostable mirror-image mixed (l-)RNA/DNA aptamer (Spiegelmer) that binds to mouse and human C5a with picomolar affinity. In vitro, NOX-D20 inhibited C5a-induced chemotaxis of a CD88-expressing cell line and eff...

2015
Laure Yatime Christian Maasch Kai Hoehlig Sven Klussmann Gregers R Andersen Axel Vater

L-Oligonucleotide aptamers (Spiegelmers) consist of non-natural L-configured nucleotides and are of particular therapeutic interest due to their high resistance to plasma nucleases. The anaphylatoxin C5a, a potent inflammatory mediator generated during complement activation that has been implicated with organ damage, can be efficiently targeted by Spiegelmers. Here, we present the first crystal...

Journal: :Journal of immunology 2013
Vernon Seow Junxian Lim Abishek Iyer Jacky Y Suen Juliana K Ariffin Daniel M Hohenhaus Matthew J Sweet David P Fairlie

Monocytes and macrophages are important innate immune cells equipped with danger-sensing receptors, including complement and Toll-like receptors. Complement protein C5a, acting via C5aR, is shown in this study to differentially modulate LPS-induced inflammatory responses in primary human monocytes versus macrophages. Whereas C5a enhanced secretion of LPS-induced IL-6 and TNF from primary human ...

Journal: :Journal of immunology 1999
B J Czermak V Sarma N M Bless H Schmal H P Friedl P A Ward

Under a variety of conditions, alveolar macrophages can generate early response cytokines (TNF-alpha, IL-1), complement components, and chemotactic cytokines (chemokines). In the current studies, we determined the requirements for TNF-alpha and the complement activation product C5a in chemokine production in vitro and in vivo. Two rat CXC chemokines (macrophage inflammatory protein (MIP)-2 and ...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2013
Antonis Ioannou Linda A Lieberman Jurandir J Dalle Lucca George C Tsokos

Ischemia-reperfusion (IR) injury causes a vigorous immune response that is amplified by complement activation, leading to local and remote tissue damage. Using MRL/lpr mice, which are known to experience accelerated tissue damage after mesenteric IR injury, we sought to evaluate whether complement inhibition mitigates organ damage. We found that complement depletion with cobra venom factor prot...

Journal: :Microbiology 2008
Kerry J Welsh April N Abbott Shen-An Hwang Jessica Indrigo Lisa Y Armitige Michael R Blackburn Robert L Hunter Jeffrey K Actor

Trehalose 6,6'-dimycolate (TDM) is a glycolipid component of the mycobacterial cell wall that causes immune responses in mice similar to Mycobacterium tuberculosis (MTB) infection, including granuloma formation with production of proinflammatory cytokines. The precise roles of tumour necrosis factor (TNF)-alpha, complement C5 and interleukin (IL)-6 in the molecular events that lead to the initi...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
T Möller C Nolte R Burger A Verkhratsky H Kettenmann

Microglial cells are activated in response to brain insults; the mechanisms of this process are not yet understood. One of the important signaling mechanisms that might be involved in microglia activation is related to changes in the intracellular calcium concentration ([Ca2+]i). Using fluo-3 microfluorimetry, we have found that external application of the complement fragment C5a (4-10 nM) indu...

2016
John-Paul Westwood Alexander J. Mackay Gavin Donaldson Samuel J. Machin Jadwiga A. Wedzicha Marie Scully

Rise in sputum complement (C3a, C5a) levels during COPD exacerbation is associated with recovery time http://ow.ly/ZaPj303xxPf.

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