randomization is an essential component of sound clinical trials which prevents selection biases and helps in blinding the allocations. randomization is a process by which subsequent subjects enrolled into trial groups only by chance which is essentially eliminates selection biases. a serious consequence of randomization is severe imbalance among treatment groups with respect to some prognostic...

Remarkable advances in cardiovascular care have been substantially mediated by large-scale, randomized clinical trials. These trials not only have identified treatments resulting in major improvements in patient outcomes but also have enhanced our understanding of the natural history of contemporary disease and the impact of risk factors and complications. The process by which phase III clinica...

the aim of this randomized controlled clinical trial was to investigate the effect of a new iranian toothpaste and a commercially available toothpaste containing desensitizing agent (5% potassium nitrate) on dentine hypersensitivity in a 24-week study.fifty healthy volunteers, who had at least two sensitive root surfaces, completed the study period. the participants were randomly given one of t...

background: massive ischemic stroke causes significant mortality and morbidity in stroke patients. the main treatments for massive ischemic stroke are recombinant tissue plasminogen activator (rtpa), craniotomy, and endovascular interventions. due to destructive  effects  of   bradykinin  on  the  nervous system in ischemic stroke, it seems reasonable that using noscapine as a bradykinin antago...

introduction: the prevalence of hypertension in patients with type 2 diabetes (t2d) is approximately twice as much as healthy people. this study was designed to determine the effect of l-arginine supplementation on blood pressure in patients with t2d. methods: in a double-blind randomized clinical trial, 75 t2d were randomly divided into three groups (3 g/d and 6 g/d of l-arginine and placebo) ...

asparagus racemosus willd. has repeatedly been mentioned as a galactogogue in ayurvedic literature and has been confirmed through animal experiments as well. this randomized double-blind clinical trial evaluates its galactogogue effect in 60 lactating mothers by measurement of changes in their prolactin hormone level during the study. several secondary parameters namely mothers’ weight, babies’...

introduction:   palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. the most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local puva. frequently, it is a recalcitrant disease. we investigated the efficacy and tolerability of the combination of topical calcipot...

introduction: performing correct research in different aspects of community as well as medical sciences can be a way to resolve many problems. in order to create a systematic knowledge of research method in academic members of arak university of medical sciences and enabling them in providing proposals and performing researches, a clinical research center was developed. this study is done to in...

background menopause is a period of women’s lives with changes and symptoms that affect their work, sleep and quality of life. therefore, it is important to overcome these symptoms. objectives the aim of the present study was to compare the effects of calci soya balance and vitagnus on menopausal symptoms. patients and methods this double-blinded controlled trial study was performed in public h...