نتایج جستجو برای: combinatorial library
تعداد نتایج: 162675 فیلتر نتایج به سال:
It is practically impossible in a short period of time to synthesize and test all compounds in any large exhaustive chemical library. We discuss rational approaches to selecting representative subsets of virtual libraries that help direct experimental synthetic efforts for both targeted and diverse library design. For targeted library design, we consider principles based on the similarity to le...
A strategy for generating large numbers of peptides from a relatively small number of precursors based on photosynthetic combination in the gas phase is presented. In this approach, electrospray ionization is used to create a combination of proton-bound dimers from a specified set of peptides present in solution. The dimers are then accumulated and isolated in an ion trap mass spectrometer. Pho...
Conventional one-bead one-compound (OBOC) library synthesis is typically used to identify molecules with therapeutic value. The design and synthesis of OBOC libraries that contain molecules with imaging or even potentially therapeutic and diagnostic capacities (e.g. theranostic agents) has been overlooked. The development of a therapeutically active molecule with a built-in imaging component fo...
Binary patterning of polar and nonpolar amino acids has been used as the key design feature for constructing large combinatorial libraries of de novo proteins. Each position in a binary patterned sequence is designed explicitly to be either polar or nonpolar; however, the precise identities of these amino acids are varied extensively. The combinatorial underpinnings of the "binary code" strateg...
The mallba project tackles the resolution of combinatorial optimization problems using algorithmic skeletons implemented in C++. mallba offers three families of generic resolution methods: exact, heuristic and hybrid. Moreover, for each resolution method, mallba provides three different implementations: sequential, parallel for local area networks, and parallel for wide area networks (currently...
types of combinatorial libraries, such as random shuffling libraries and artificial alternative splicing libraries. The block shuffling and random point mutations can be introduced simultaneously by performing RMPCR under error-prone conditions. Most of the block sequences in the combinatorial libraries created by RM-PCR encode a long open reading frame and are suitable for protein selection ex...
A combinatorial histidine scanning library approach to engineer highly pH-dependent protein switches
A combinatorial optimization problem, called the Bandpass Problem, is introduced. Given a rectangular matrix A of binary elements {0,1} and a positive integer B called the Bandpass Number, a set of B consecutive non-zero elements in any column is called a Bandpass. No two bandpasses in the same column can have common rows. The Bandpass problem consists of finding an optimal permutation of rows ...
A combinatorial library of lipidoids was constructed and studied for in vitro gene delivery. The library of lipidoids was synthesized by reacting commercially available amines with lipophilic acrylates, acrylamides, or epoxides. Lipidoids derived from amine 86 (N,N-bis(2-hydroxyethyl)ethylene diamine) and amine 87 (N-(3-aminopropyl)diethaneamine) showed high efficiency in DNA delivery, some wit...
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