A recent chordoma cancer genotyping study reveals that the rs2305089, a single nucleotide polymorphism (SNP) located in brachyury gene and a key gene in the development of notochord, is significantly associated with chordoma risk. The brachyury gene is believed to be one of the key genes involved in the pathogenesis of chordoma, a rare primary bone tumor originating along the spinal column or a...

A material suitable for base-pair-specific "affinity chromatography" of double stranded DNA is described. The synthesis of this material involves two successive polymerization reactions yielding solid particles of cross-linked bisacrylamide to which base-pair-specific dyes are covalently attached by spacers of polyacrylamide chains of different length. Materials with immobilized A.T-specific ma...

Pineoblastoma is a rare malignant tumor of the central nervous system (CNS), which arises from the parenchyma of the pineal gland. It is characterized by aggressive clinical behavior and frequent metastases along the craniospinal axis. Extraneural metastases may occur due to surgical seeding of tumor cells beyond the dura and/or hematogenous spread, ventriculoperitoneal shunting, or through Bat...

Ion-exchange particles in which functionalized secondary polymers have been grafted onto the base matrix have been shown to offer significant performance advantages over traditional particles, especially with respect to increases in dynamic binding capacity (DBC). However, the mechanistic origins of these advantages are not clearly understood. A number of studies have found that, depending on p...

This paper considers the design and control of a reactive distillation column in which one reactant is consumed and two products are formed (A B+C). The volatilities are B ¿ A ¿ C , i.e. the reactant is intermediate boiling between the two products. The metathesis of 2-pentene is considered as the demonstrative example. The column has a single feed of the intermediate boiling reactant. The dist...

This paper addresses the mobile assignment problem in a multi-cell broadcast transmission seeking minimal total power consumption by considering both transmission and operational powers. While the large scale nature of the problem entails to find distributed solutions, game theory appears to be a natural tool. We propose a novel distributed algorithm based on group formation games, called the h...

This paper proposes a new type of steel slip-friction column base connections with arc end-plates. Two end-plates the base, which can slide between each other to some extent, were set at position where is subject plastic deformation. Thus, sliding-friction energy dissipation effectively minimize or eliminate traditional connections. Cyclic loading tests conducted study hysteretic performance an...

The cyclic loading performance of bamboo double-jointed components different column base connection types was investigated through reversed tests and finite element analysis. Test results indicated that the connections played an important role in failure modes engineered columns: for encased steel plate connection, main mode tensile fracture scrimber section at bottom cladding plate; a slotted-...

Pull-out fracture of lag-screw bolt is brittle and has a large dispersion in strength. therefore, the bucking pipe preceding pull-out controls strength toughness joint. The sandwiched between bolts fixed to base plate. method little dispersion, can be controlled by adjusting thickness length effect was confirmed experiments. it also that once maximum load reached, restored exchanging pipe.