نتایج جستجو برای: colorectal cancer cell line
تعداد نتایج: 2622543 فیلتر نتایج به سال:
Oncogenic BRAF, which drives cell transformation and proliferation, has been detected in approximately 50% of human malignant melanomas and 5% to 15% of colorectal cancers. Despite the remarkable clinical activities achieved by vemurafenib and dabrafenib in treating BRAF(V600E) metastatic melanoma, their clinical efficacy in BRAF(V600E) colorectal cancer is far less impressive. Prior studies su...
Metastatic ovarian cancers occur in 3-8 percent of women undergoing surgical resection of a primary colorectal cancer. In this study we examined the characteristics of women with colorectal cancer for whom synchronous oophorectomy had been performed. In this cross-sectional study, records of patients with colorectal cancer from April 1991 through October 1999 who had undergone surgery for both...
Background: The Connective Tissue Growth Factor (CTGF) gene encoding an extracellular matrix (ECM)-associated protein and as a member of the CCN family of proteins plays a major role in fibrosis, inflammation and connective tissue remodeling in a variety of diseases including cancer. The CCN proteins are multifunctional and are involved in cell proliferation, adhesion and cell development durin...
We previously showed that L-arginine (Arg) accumulates in colorectal cancer tissues. The aim of this study was to investigate the mechanism by which Arg accumulates and determine its biological significance. The concentration of Arg and Citrulline (Cit) in sera and tumor tissues from colorectal cancer (CRC) patients was analyzed by high-performance liquid chromatography (HPLC). The expression o...
BACKGROUND The Beclin 1 gene binds to the apoptosis-inhibiting protein Bcl-2. The expression and function of the Beclin 1 gene in four colorectal cancer cell lines (HT29, DLD-1, SW480, SW620) was investigated. MATERIALS AND METHODS The expression of Beclin 1 mRNA was examined by reverse transcription-polymerase chain reaction (RT-PCR), the cell growth rate of a stable cell line established af...
Cetuximab, an epidermal growth factor receptor (EGFR)-blocking antibody, was approved for treatment of metastatic colorectal cancer over a decade ago; however, patients' responses to cetuximab vary substantially due to intrinsic and acquired resistance to cetuximab. Here, we report our findings using Affymetrix HG-U133A array to examine changes in global gene expression between DiFi, a human co...
introduction: detection of malignant cells in the peritoneal cavity indicates the extension of cancer cells. the aim of this study is to evaluate the incidence rate of positive cytology in colorectal cancer and its relationship with the local progress of the tumor. methods: in a 2-year prospective study in mashhad and iran universities of medical sciences, peritoneal lavage was performed on 40...
A number of patients exhibit peritoneal dissemination of gastric or colorectal cancer, which is a predominant cause of cancer-associated mortality. Currently, there is no markedly effective treatment available. The present study was designed to determine the efficacy of trifluridine/tipiracil (TFTD), formerly known as TAS-102, which is used for the treatment of patients with unresectable advanc...
Background & Aims : Breast cancer is the most common cancer in women. The aim of this study was to investigate the effects of electromagnetic field on MCF-7 cancer cell line . Materials & Methods : MCF-7 cell lines and L929 cell line were cultured in RPMI medium that contain fetal bovine serum and antibiotics . Cells for three hours were exposed to 50 Hz electromagnetic field with intensi...
the antioxidant and cytotoxic properties of four major parts of methanolic extracts of tephrosia purpurea including leaves, root, stem and seed were investigated and compared. in vitro antioxidant activity of t. purpurea extracts was evaluated using 1,1-diphenyl-2-picrylhydrazyl (dpph), ferric reducing antioxidant power (frap), reducing power assay and antihemolytic assay. in vitro cytotoxic ef...
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