The cholinesterase inhibitor neostigmine indirectly stimulates muscarinic M(1)/M(2)/M(3) receptors, thereby reducing colonic distension in acute colonic pseudo-obstruction. We investigated the dose-response profile for the colonic sensorimotor effects of neostigmine and bethanechol, a direct muscarinic M(2)/M(3) agonist in humans. A barostat-manometric assembly recorded phasic pressures, tone, ...

Colonic arteriovenous malformations (AVMs) are well recognized in the literature and commonly manifest as colitis, abdominal pain, rare cases have been reported of liver congestion. Dual-supply superior artery/ inferior mesenteric artery (SMA/IMA) colonic AVMs never only one case treating portal hypertension due to an AVM with endovascular approach has reported. We present a dual-supply SMA/IMA...

introduction and aims: we noticed in our practice that the patients with ulcerative colitis (uc) who have developed primary sclerosing cholangitis (psc) experience a milder course of colonic disease. our objective in this study was to define whether there is any difference between uc activity and its course in patients with and without psc. materials and methods: 19 patients with uc and psc (8 ...

Abstract Aims Colonic perforation is an adverse event of colonoscopy. This around 1/1500 in diagnostic colonoscopy, 1/500 polypectomy procedures & 1/50 EMR procedure. study to evaluate the management colonic at a single centre. Methods Colonoscopy carried out on patients with colorectal cancer symptoms, family history, polyp surveillance. Retrospective since 2012 all colonoscopies evaluatio...

We studied the functional importance of the colonic guanylyl cyclase C (GCC) receptor in GCC receptor-deficient mice. Mice were anesthetized with pentobarbital sodium, and colon segments were studied in Ussing chambers in HCO3- Ringer under short-circuit conditions. Receptor-deficient mouse proximal colon exhibited similar net Na+ absorption, lower net Cl- absorption, and a negative residual io...

background: to compare the efficacy of metronidazole versus placebo in the control of gaseous symptoms inpatients with functional bowel disease. materials and methods: in the absence of organic or systemic diseases, all cases with chief complaints of bloating and normal laboratory tests were consecutively enrolled in this double-blind study. lactase deficiency and bacterial overgrowth were rule...

background: early diagnosis and endoscopic resection of adenomatous polyps is the main approach for screening and prevention of colorectal cancer (crc). we aimed to assess polyp detection rate (pdr) and to characterize demographic, clinical, and pathological features of colorectal polyps in an iranian population. methods: we retrospectively analyzed the data from 5427 colonoscopies performed du...

to access the surgical progress of patients with long segment aganglionosis and long-term evaluation. during the past 15 years, we reviewed the therapy and outcome of 15 patients with long-segment agangelionosis (lsa) in mofid children's hospital. 2 with agangelionosis to the midtransvers colon (mta(, 8 to the ascendant and cecum (a/ca), 4 with total colonic and distal ileum involvement (tca), ...

Limited data in animal models suggest that colonic mucosa undergoes adaptive growth following massive small bowel resection (SBR). In vitro data suggest that intestinal cell growth is regulated by reactive oxygen species and redox couples [e.g., glutathione (GSH)/glutathione disulfide (GSSG) and cysteine (Cys)/cystine (CySS) redox]. We investigated the effects of SBR and alterations in redox on...