BACKGROUND Dupuytren's disease (DD) is a debilitating fibro-proliferative disorder of the hand characterized by the appearance of fibrotic lesions (nodules and cords) leading to flexion contractures of the fingers and loss of hand function. Although the molecular mechanism of DD is unknown, it has been suggested that transforming growth factor-beta2 (TGF-beta2) may play an important role in the...

INTRODUCTION The need of this study is to assess the role of collagen III in all hernias which include primary inguinal hernias ventral and recurrent abdominal hernias. Collagen type III represents the mechanically instable, less cross-linked collagen synthesized during the early days of wound healing. Quantitative assessment of collagen III in scar tissue on transversalis fascia as tissue obta...

There is no proven therapy or prevention for vascular Ehlers-Danlos syndrome (vEDS), a genetic disorder associated with the mutation of procollagen type III and characterized by increased fragility of vascular and hollow organ walls. Heterozygous COL3A1-deficient (HT) mice recapitulate a mild presentation of one of the variants of vEDS: haploinsufficiency for collagen III. Adult HT mice are cha...

Stimulation of the platelet nonintegrin collagen receptor, glycoprotein VI, evokes a signaling response similar to that induced by antigen receptor activation in B and T lymphocytes. A key transducer of the lymphocyte signaling pathways is the Bruton's tyrosine kinase (Btk)/Tec kinase family, which connects receptors to the elevation of intracellular-free calcium levels. An important signaling ...

Oral submucous fibrosis (OSF) is a precancerous condition of the oral cavity. It is a collagen-related disorder induced by betel quid chewing, a habit that is common in Taiwan. However, the cumulative exposure to betel quids varies in OSF patients. It seems that there is individual susceptibility to betel quid-induced OSF. This study compared the association of OSF and polymorphisms of six coll...

von Willebrand factor (VWF) plays an important role in coagulation as a carrier protein for factor VIII (FVIII) and in primary hemostasis with binding of VWF to exposed subendothelial collagens. The most hemostatically important forms of collagen include the fibrillar collagens I and III, and the microfibrillar collagen VI. VWF binds to collagen I and III via theVWFA1andA3domainswhereas only th...

introduction: we did this study because there were a few studies about aorto-branch junction. methods: four light microscope and electron microscope study, the abdominal aorta, renal artery, and the adjoining right and left renal arteries were dissected out from 4 neonate dogs. results: based on the results, there is only one cell type in the tunica intima of endothelium in both arteries. in ab...

conclusions alterations were present in both the aspect and spacing of collagen fibrils and in the shape of elastic fibers. the present familial combination of scad and edsh, with almost similar ultrastructural features suggests a possible connection between both conditions. case presentation we present a woman with scad and her five close relatives showing obvious or suggestive signs of edsh. ...

combination formulations of liposomes with collagen have been previously introduced as a means of obtaining more stable and less permeable liposomes. in this study, the effect of aqueous solutions of the collagen products collapur? (col) and collapuron-dak? (cold) from henkle co., on the release rate of sodium chromate (chr) as a water-soluble model drug from stable plurilamellar vesicles (splv...