Two aldimine bonds have been shown to be present as stabilizing cross-links in intact collagen fibres from soft tissues: dehydrohydroxylysinonorleucine as a major component and dehydrolysinonorleucine being present in trace quantities. In the highly insoluble collagens less dehydrohydroxylysinonorleucine is present but the proportion of dehydrolysinonorleucine increases. In elastin the latter a...

Fibrillar collagens, common tissue scaffolds in live organisms, can also self-assemble in vitro from solution. While previous in vitro studies showed that the pH and the electrolyte concentration in solution largely control the collagen assembly, the physical reasons why such control could be exerted are still elusive. To address this issue and to be able to simulate self-assembly over large sp...

Recently, hydrogen-fuel cells have attracted attention as an environmentally friendly next-generation energy device. Very recently, biomaterials such collagen and chitin realized proton conductivity via water bridges under humidity condition, the fabrication of fuel using is possible. However, cell electrolyte has demerits, complication instruments operating temperature limit. Therefore, electr...

Background Von Willebrand factor (VWF) contains a number of free thiols, the majority which are located in its C-domains, and these have been shown to alter VWF function, However, impact thiols on function following acute exposure collagen under high pathological shear stress has not determined. Methods were blocked with N-ethylmaleimide flow assays performed rates determine platelet capture bi...

Collagen is the most abundant protein in humans. It has a characteristic triple-helix structure and heavily posttranslationally modified. The complex biosynthesis of collagen involves processing by many enzymes chaperones rough endoplasmic reticulum. Lysyl hydroxylase 1 (LH1) required to hydroxylate lysine for cross-linking carbohydrate attachment within triple helical sequences. Additionally, ...

This CIBA Symposium on the intestinal mucosa represents a timely review of dissecting, light, and electron microscopic studies of the small bowel. Booth, et al. describes dissecting microscopic changes in the small bowel, some of which could not be appreciated by the light microscope. The dissecting microscope appears to be widely employed by the British and Europeans, but neglected by the Amer...