نتایج جستجو برای: colchicine treatment
تعداد نتایج: 1397601 فیلتر نتایج به سال:
Patients with gout are more likely to develop most cancers than subjects without gout. Colchicine has been used for the treatment and prevention of gouty arthritis and has been reported to have an anticancer effect in vitro. However, to date no study has evaluated the relationship between colchicine use and incident cancers in patients with gout. This study enrolled male patients with gout iden...
We have studied the effect of colchicine and related compounds on secretion of enzymes by thioglycollated-elicited mouse peritoneal macrophages in culture. Colchicine stimulated secretion of inducible neutral proteinase activities of elastase (EC 3.4.21.11), collagenase (EC 3.4.24.3), gelatinase (pepsin B; EC 3.4.23.2), and azocaseinase 2- to 6-fold for a period of several days, but inhibited t...
Polyploidy, frequently observed in citrus species, aids achieving better adaptation to environmental stresses. In this context, the current work aims develop stable tetraploids rootstock cultivars, viz., Rough lemon, Rangpur lime and Alemow, through vitro colchicine treatments. Seed-derived explants were obtained by culturing sterile seeds on MS basal media. Seedlings with a size of 5–8 mm (hyp...
PURPOSE To investigate if colchicine is valuable in the treatment of Graves' ophthalmopathy (GO), we compared its effect with prednisone in 22 patients during the inflammatory phase of GO. METHODS All patients, similar in age, sex and smoking habits, were euthyroid for at least 3 months and randomly divided into two groups, one treated with colchicine (1.5 mg/day) and the other treated with p...
OBJECTIVE Colchicine is an alkaloid that is used to alleviate acute gout and to prevent acute attacks of familial Mediterranean fever (FMF). However, it is not beneficial when given during the occurrence of an acute episode of FMF. It is believed that colchicine exerts its anti-inflammatory effect through direct interaction with microtubules. We aim to study the molecular basis of colchicine ac...
Studies were conducted to explore the effects of colchicine on the secretion and metabolism of retinol-binding protein (RBP) by the liver. In the vitamin A-deficient rat, the rate of secretion of RBP from the liver into the serum is greatly reduced, and RBP accumulates in the liver. Injection of retinol (dispersed in a 20% Tween 40 solution) into deficient rats stimulated a rapid secretion of R...
Introduction Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder characterized by recurring attacks of fever accompanied by intense pain in the abdomen, chest, or joints. Colchicine, is an important drug which is used in diseases such as FMF and acute gout attacks. However, it has significant side effects such as diarrhea, nausea, vomiting and fatigue. Some of the patie...
The present study investigated the effect of colchicine and trimethylcolchicinic acid on liver fibrosis induced by common bile duct ligation in albino rats. Bile duct ligated rats showed cirrhosis where liver architecture completely distorted with diffused fibrosis and generation of abnormal nodules. Hepatocytes with nuclear changes and highly proliferated bile ductules were also detected. Alph...
A case of colchicine-induced rhabdomyolysis is reported. The 72-year-old man was hospitalized because of poor appetite, fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine for 5 months. Laboratory results revealed serum creatine kinase: 3627 IU/L, creatinine: 2.3 mg/dL, myoglobin: 1160.5 ng/mL (reference range: male: 17.4-105.7 ng/mL, female: 14.3-65.8 ng/mL) an...
Abstract The aim of this study was to investigate secondary metabolite production in Silybum marianum L. cell suspension cultures obtained from seeds treated with gamma rays (200 and 600 Gy) 0.05% colchicine. effects these treatments on callus induction, growth, viability, silymarin were studied, along the changes transcriptome DNA sequence chalcone synthase (CHS) genes. effect radiation S. dry...
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