Activation of the cannabinoid CB1 receptor (CB1) is modulated by aspartate residue D2.63(176) in transmembrane helix (TMH) 2. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A G protein-coupled receptors have suggested an ionic interaction between residues of TMH2 and 7. In this report, modeling studies identified residue K373 in the ex...

Background: Infertile couples in the reproductive failure, after a year of sex without contraception is described and in 10 to 15% of couples can be seen, that the 1/3 because of the male, 1/3 female and the rest are a common cause. Factors involved in human infertility, the expression of microbial infection (25%), biological factors, environmental and genetic (50%) and unknown causes (25%) are...

Incubation of INT407 cells with various clinical isolates of Campylobacter jejuni resulted in secretion of interleukin-8 (IL-8) at levels ranging from 96 to 554 pg/ml at 24 h. The strains which produced the highest levels of IL-8 secretion were 81-176 and BT44. Induction of IL-8 secretion required live cells of 81-176 and was dependent on de novo protein synthesis. Site-specific mutants of 81-1...

This paper is concerned with the study of the geometry of determinant line bundles associated to families of spectral triples parametrized by the moduli space of gauge equivalent classes of Hermitian connections on a Hermitian finite projective module. We illustrate our results with some examples that arise in noncommutative geometry. Introduction In the mid 1990s, Connes and Moscovici [4] form...

Here we demonstrate that Niche Genetic Algorithms (NGA) are better at computing protein folding than traditional Genetic Algorithms (GA). de novo Previous research has shown that proteins can fold into their active forms in a limited number of ways; however, predicting how a set of amino acids will fold starting from the primary structure is still a mystery. GAs have a unique ability to solve t...

This purpose of this retrospective study is validation of an intraoperative robotic grading classification system for assessing the accuracy of Kirschner-wire (K-wire) placements with the postoperative computed tomography (CT)-base classification system for assessing the accuracy of pedicle screw placements.We conducted a retrospective review of prospectively collected data from 35 consecutive ...