Background. Freezing of Gait (FOG) is a disabling parkinsonian symptom. The Freezing of Gait Questionnaire (FOG-Q) reliably detects FOG in patients with Parkinson's disease (PD). Objectives. The aim of this study was to develop a German translated version of the FOG-Q and to assess its validity. Methods. The translation was accomplished using forward-backward-translation. The construct validity...

Intramolecular remote coupling within the polypeptide backbones of membrane proteins is difficult to analyze owing to the limited structural information available at the atomic level. Nonetheless, recent progress in the crystallographic study of G protein-coupled receptors (GPCRs) has provided an unprecedented opportunity for understanding the sophisticated architecture of heptahelical transmem...

Here dw denotes the Lebesgue measure on the unit sphere, normalized to make ∫ S2 dw = 1. The famous Moser-Trudinger inequality says that J1 is bounded below by a non-positive constant C1. Later Onofri [6] showed that C1 can be taken to be 0. (Another proof was also given by OsgoodPhillips-Sarnack [7].) On the other hand, if we restrict Jα to the class of G of functions g for which e2g has centr...

In this article, we analyze the boundary behavior of solutions to the boundary blow-up elliptic problem ∆u = b(x)f(u), u ≥ 0, x ∈ Ω, u|∂Ω =∞, where Ω is a bounded domain with smooth boundary in RN , f(u) grows slower than any up (p > 1) at infinity, and b ∈ Cα(Ω̄) which is non-negative in Ω and positive near ∂Ω, may be vanishing on the boundary.

In this work we present a new method for investigating local energy minima on a protein energy landscape. The CABS (CAlpha, CBeta and the center of mass of the Side chain) method was employed for generating protein models, but any other method could be used instead. Cα traces from an ensemble of models are hierarchical clustered with the HCPM (Hierarchical Clustering of Protein Models) method. ...

Oxidative stress has been implicated as an important contributing factor in the pathogenesis of several pulmonary inflammatory diseases. Previous studies have indicated a relationship between oxidative stress and the attenuation of epithelial tight junctions (TJs). In Human Bronchial Epithelial-16 cells (16HBE), we demonstrated the degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibit...

Overexpression and mutational activation of the epidermal growth factor receptor (EGFR) plays an important role in the pathogenesis of non-small cell lung cancer (NSCLC). EGFR tyrosine-kinase inhibitors (TKIs) are given as a primary therapy for advanced patients with EGFR-activating mutations; however, the majority of these tumors relapse and patients eventually develop resistance to TKIs. To a...