Aims To ascertain the effect of SARS-CoV-2 on utilisation antibacterial agents and analgesics in primary dental care. Methods Antibacterial (eg paracetamol, aspirin) prescribed England by general practitioners for periods April-July 2019 2020 were analysed. Results during COVID-19 restrictions (799,282) higher than a similar time period (654,332) 22%. Amoxicillin was used most (2020 = 65.0%; 66...

A 25-year-old non-smoking warehouse worker presented to the acute medical take with a five-day history of worsening symptoms including anorexia, lethargy, myalgia, swinging fevers and night sweats. He had been seen by his general practitioner at the start of this illness and commenced on oseltamivir to treat presumed H1N1 influenza; subsequent hospital referral was prompted by worsening oral in...

BACKGROUND Restriction of antibiotic consumption to below predefined total use thresholds might remove the selection pressure that maintains antimicrobial resistance within populations. We assessed the effect of national antibiotic stewardship and infection prevention and control programmes on prevalence density of meticillin-resistant Staphylococcus aureus (MRSA) infections across a region of ...

A cross-sectional study was performed to determine the prevalence of antibiotic resistance in women with uncomplicated and complicated lower urinary tract infection (UTI) in Germany. In 36 (of 118 invited) general practices, urine cultures and resistance testing were performed during 4 months on all women presenting with symptoms of UTI. Each patient's symptoms, risk factors and treatment were ...

OBJECTIVES A Trust strategy to reduce ciprofloxacin use was implemented at a University hospital. This study aimed to investigate whether the susceptibility of Gram-negative organisms (GNO) to alternative antimicrobials (co-amoxiclav, doxycycline, aztreonam, piperacillin/tazobactam, meropenem and gentamicin) changed, and whether there was any relationship between GNO susceptibility to these ant...

BACKGROUND Antibiotics used for women in spontaneous preterm labour without overt infection, in contrast to those with preterm rupture of membranes, are associated with altered functional outcomes in their children. METHODS From the National Pupil Database, we used Key Stage 2 scores, national test scores in school year 6 at 11 years of age, to explore the hypothesis that erythromycin and co-...

The aims of this investigation were to calculate the pharmacokinetic parameters of amoxicillin and clavulanic acid, and to identify parameters that may affect their observed differences in absorption. Data were obtained from plasma concentration-time curves from four different open, randomized, two-treatment, two-period, two-sequence, crossover Phase I bioequivalence studies, with the following...