نتایج جستجو برای: cns tumors
تعداد نتایج: 279888 فیلتر نتایج به سال:
The central nervous system (CNS) possesses powerful local and global immunosuppressive capabilities that modulate unwanted inflammatory reactions in nervous tissue. These same immune-modulatory mechanisms are also co-opted by malignant brain tumors and pose a formidable challenge to brain tumor immunotherapy. Routes by which malignant gliomas coordinate immunosuppression include the mechanical ...
Through advances in genome science, we are becoming increasingly aware that tumors that appear identical under the pathologist's microscope can be very different in their genetic composition and clinical behavior. Pediatric embryonal brain tumors share a characteristic histological feature—densely packed sheets of cells with hyperchromatic nuclei and scant cytoplasm. Despite their common appear...
Introduction An estimated 17,000 new cases of primary central nervous system (CNS) tumors will be diagnosed in the United States in 2002 (1). The number of related deaths is projected to be 13,100. These numbers represent a small proportion of the total number of new cancer cases and cancer deaths; however, because of the diversity and complexity of CNS tumors, a multidisciplinary approach is r...
ETS-related gene (ERG) is a transcription factor that has been linked to angiogenesis. Very little research has been done to assess ERG expression in central nervous system (CNS) tumors. We evaluated 57 CNS tumors, including glioblastomas (GBMs) and hemangioblastomas (HBs), as well as two arteriovenous malformations and four samples of normal brain tissue with immunohistochemistry using a speci...
Recent studies have shown that the brain is not a barrier to successful active immunotherapy that uses gene-modified autologous tumor cell vaccines. In this study, we compared the efficacy of two types of vaccines for the treatment of tumors within the central nervous system (CNS): dendritic cell (DC)-based vaccines pulsed with either tumor extract or tumor RNA, and cytokine gene-modified tumor...
PURPOSE Cancer spread to the central nervous system (CNS) often is diagnosed late and is unresponsive to therapy. Mechanisms of tumor dissemination and evolution within the CNS are largely unknown because of limited access to tumor tissue. MATERIALS AND METHODS We sequenced 341 cancer-associated genes in cell-free DNA from cerebrospinal fluid (CSF) obtained through routine lumbar puncture in ...
PURPOSE Reasons for worldwide variability in the burden of primary malignant brain and central nervous system (CNS) tumors remain unclear. This study compares the incidence and survival of malignant brain and CNS tumors by selected histologic types between the United States (US) and Taiwan. METHODS Data from 2002 to 2010 were selected from two population-based cancer registries for primary ma...
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