PURPOSE Prognosis and outcome of children with isolated CNS relapse of acute lymphoblastic leukemia (ALL) has depended on duration of first complete remission (CR1). This study intensified systemic therapy by delaying CNS radiation for 12 months and tailored CNS radiation by CR1 duration. PATIENTS AND METHODS Seventy-six children with first isolated CNS relapse of ALL were treated with system...

UNLABELLED Primary breast lymphoma (PBL) is a rare disease accounting for 0.4-0.5% of all breast malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common histological diagnosis. The clinical presentation of PBLs is usually no different from that of carcinoma. In this paper we review the literature on the clinical presentation, diagnosis, prognostic factors and treatment options of...

OBJECTIVE To determine the pattern of childhood cancer in northern Pakistan. DESIGN A descriptive study. PLACE AND DURATION January 1992 to December 2001 at the Armed Forces Institute of Pathology, Rawalpindi, Pakistan. MATERIALS AND METHODS All histologically diagnosed malignant childhood tumours registered with the tumour registry of our institute were retrieved from the case files. Bas...

Imaging plays a key role in the diagnosis of central nervous system (CNS) metastasis. Imaging is used to detect metastases in patients with known malignancies and new neurological signs or symptoms, as well as to screen for CNS involvement in patients with known cancer. Computed tomography (CT) and magnetic resonance imaging (MRI) are the key imaging modalities used in the diagnosis of brain me...

OBJECTIVE To report an unusual case of synchronous renal cell carcinoma and CNS lymphoma in a patient with autosomal dominant polycystic kidney disease (ADPKD). CASE PRESENTATION AND INTERVENTION A 58-year-old woman presented with progressive right hemiparesis of 2 months' duration. A brain CT scan revealed multiple enhanced lesions in the basal ganglia and the right occipital lobe. CNS lymph...

BACKGROUND Cerebrospinal fluid (CSF) examination can be used to verify the presence of primary malignancies as well as cases of central nervous system (CNS) metastasis. Because of its importance, there have been several studies concerning the sensitivity of CSF cytology. To determine the practical use and reproducibility of diagnoses based on CSF cytology, we evaluated this test by analyzing cy...