Abstract INTRODUCTION Central nervous system (CNS) metastasis from nasopharyngeal carcinoma (NPC) is rare and presents with high morbidity mortality. As a entity, few patients CNS NPC have been reported, no studies were available on treatment prognosis. Based our clinical experience, early diagnosis incorporation of clear palliative plan imperative in providing holistic care for locally-invasiv...

Inflammation is portion of the body's immune response and it is basically a host protective response to tissue ischemia, injury, autoimmune responses or infectious agents. Although the information presented so far points to a detrimental role for inflammation in central nervous system (CNS) disease, it may also be useful. CNS demonstrates characteristic of inflammation, and in response to damag...

BACKGROUND Von Hippel-Lindau (VHL) is an uncommon oncogenic disorder which occurs as a result of genetic mutations on chromosome 3p. Retinal capillary haemangiomas and CNS haemangioblastomas have been well-characterised in genotypic-phenotypic analyses, but cystic visceral lesions are less common and have been less frequently studied. The aim of this study was to perform genotypic and phenotypi...

Background: Spinal cord tumors represent 2-4% of all CNS tumors. Ependymomas are the most frequent lesions spinal cord1. Gross total resection remains gold standard2. Method: We describe mini-invasive surgical technique using a fixed tubular retractor performed for an ependymoma filum terminale, along with its advantages and limits. Conclusion: This has shown to be safe effective terminale epen...

CNS involvement in Langerhans cell histiocytosis (LCH) is a rare but potentially devastating disorder. Different types of involvement have been described by MRI. CNS changes can have space-occupying or degenerative character. Little is known about the underlying neuropathology and pathophysiology. In our study we reviewed brain samples from 12 patients with LCH. The neuropathology findings were...

The receptor for nerve growth factor (NGF) comprises a 75-kDa (NGFRp75) and a tyrosine kinase A (TrkA) subunit. In view of conflicting opinions on the identity of glial targets of NGF in human central nervous system (CNS), we examined the cellular distribution of both NGF receptor subunits in normal CNS and in chronic multiple sclerosis (MS) lesions. For this, we compared the pattern of recogni...

Neurologic manifestations of lymphomatoid granulomatosis occur in 20-30% of cases. The disease is primarily an unusual form of pulmonary angiitis, and was first described in 1972 by Liebow et al. [1] . The purpose of this paper is to show the progression and regression of CNS lesions in a 17-year-old boy who presented only with neurologic features of the disease. Patients with lymphomatoid gran...

Like humans, horses are susceptible to neurotropic and neuroinvasive pathogens that not always readily identified in histological sections. Instead, alterations astrocytes microglia cells can be used as pathological hallmarks of injured nervous tissue a variety infectious degenerative diseases. On the other hand, equine glial cell poorly characterized Therefore, this study, we provide statistic...

Extracellular matrix (ECM) molecules play important roles in the pathobiology of the major human central nervous system (CNS) inflammatory/demyelinating disease multiple sclerosis (MS). This mini-review highlights some recent work on CNS endothelial cell interactions with vascular basement membrane ECM as part of the cellular immune response, and roles for white matter ECM molecules in demyelin...