Superconvergence phenomenon of the Legendre spectral collocation method and the p-version finite element method is discussed under the one dimensional setting. For a class of functions that satisfy a regularity condition (M): ‖u‖L∞ ≤ cMk on a bounded domain, it is demonstrated, both theoretically and numerically, that the optimal convergent rate is supergeometric. Furthermore, at proper Gaussia...

The analysis of the impact cathode catalyst layer pore structure on membrane electrode assembly (MEA) cell performance a PEMFC is presented. In this study, pristine CMK-3 carbon support material with well-defined in 3–6 nm range together two nitrogen-doped variants analyzed against commercial black to achieve better understanding porosity-performance relations. We used chemically N-doped learn ...

Despite vast improvements in our understanding of cancer genetics, a large percentage of cancer cases present without knowledge of the causative genetic events. Tyrosine kinases are frequently implicated in the pathogenesis of numerous types of cancer, but identification and validation of tyrosine kinase targets in cancer can be a time-consuming process. We report the establishment of an effici...

Furin is a member of the pro-protein convertase family. It processes several growth regulatory proteins into their active forms, which are critical to tumor progression, metastasis, and angiogenesis. Furin over-expression could occur in liver cancer and a previous study showed that over-expression of furin promoted HepG2 cell invasion in tail vein xenograft models. However, the clinical relevan...

Bu çalışmada, Anayasa Mahkemesinin (Mahkeme) bireysel başvurular kapsamında, delil yasakları ve hukuka aykırı delillerin değerlendirilmesiyle ilgili içtihadı incelenecektir. İnceleme, ceza muhakemesi hukukunun ilkeleri gözetilerek yalnızca yargılamasında sınırlı olacaktır. çalışmayı hazırlamak için tespit ettiğimiz ana sorun, çalışmanın ilerleyen bölümlerinde detaylıca inceleneceği üzere, AY m....

Many different biochemical signaling pathways regulate integrin activation through the integrin cytoplasmic tail. Here, we describe a new role for α-actinin in inside-out integrin activation. In resting human platelets, α-actinin was associated with αIIbβ3, whereas inside-out signaling (αIIbβ3 activation signals) from protease-activated receptors (PARs) dephosphorylated and dissociated α-actini...

Goblet cell hyperplasia in the superficial airway epithelia is a signature pathological feature of chronic bronchitis and cystic fibrosis. In these chronic inflammatory airway diseases, neutrophil elastase (NE) is found in high concentrations in the epithelial lining fluid. NE has been reported to trigger mucin secretion and increase mucin gene expression in vitro. We hypothesized that chronic ...

The adaptor protein, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), connects pathogen/danger sensors such as NLRP3 and NLRC4 with caspases and is involved in inflammation and cell death. We have found that ASC activation induced caspase-8-dependent apoptosis or CA-074Me (cathepsin B inhibitor)-inhibitable necrosis depending on the cell type. Unlike necrop...