In the current study, the effects of ethanol (EtOH) on toxicokinetics of methamphetamine (MA) and its metabolite amphetamine (AP) were investigated. A single dose of MA hydrochloride at 15 mg/Kg was given intragastrically, either alone (MA group; n = 8) or in conjunction with 3 g/Kg EtOH (MA+EtOH group; n = 8) to rabbits. In placebo group, normal saline only was given (placebo group; n = 4). Pl...

Glimepiride/metformin(2/500mg) is an oral antihyperglycemic agent for the treatment of type 2 diabetes. A generic glimepiride/metformin(2/500mg) fixed-dose combination(FDC) tablet was developed recently. This study was designed to collect data for submission to Korean regulatory authorities to allow the marketing of the test formulation. We evaluated the comparative bioavailability and tolerabi...

Scheduling concerns the allocation of limited resources overtime to perform tasks fulfill certain criterion and optimize one or several objective functions. One most popular models in scheduling theory is that flow-shop scheduling. During last 40 years, permutation sequencing problem with makespan minimization has held attraction many researchers. This characterized as Fm/prmu/Cmax notation Gra...

Abstract Panobinostat is an HDAC inhibitor with dose-dependent pre-clinical activity against pediatric glioma. Reported pharmacokinetic (PK) profiles of panobinostat, including CSF penetration, have varied. We hypothesized that this variability resulted from the utilization differing panobinostat formulations. For comparison to USP grade powdered formulation PK profile formerly reported (Rodger...

Evidence of pain perception in fish is well established, but analgesic use aquaculture limited. The objective was to investigate the comparative pharmacokinetics flunixin administered intramuscularly (IM) and meloxicam IM or orally (PO) tilapia. Two hundred seventy were assigned 1 3 treatment groups: meglumine (2.2 mg/kg); (1 PO mg/kg). Blood tissue samples collected from 6 per at 14 time point...

Background: Progesterone, one of a class neurosteroids, has been linked to seizure control. However, the pharmacokinetics progesterone and its active metabolite, allopregnanolone, have never investigated among patients with drug-resistant epilepsy (DRE). Objective: To investigate progesterone, 400 mg micronized per oral every 12 hours for three months, DRE as an add-on therapy The pharmacokinet...

The roots of Salvia miltiorrhiza (Danshen) is a precious herbal medicine used to treat cardiovascular diseases. This study establishes high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method quantify seven bioactive constituents from Danshen in rat plasma simultaneously. Chromatographic separation performed on an Agilent Eclipse Plus C18 column (150 mm × 2.1 mm, 5 μ...

A new tablet system was examined for an intestinal delivery using hydroxypropyl methylcellulose (HPMC) and shellac. HPMC incorporated into the inside of tablet, shellac coated on surface, which evaluated its controlled-release property through several dissolution tests, firstly in vitro then via two kinds clinical studies with healthy volunteers. The were originally designed by employing X-ray ...

In vitro studies were designed to investigate the influence of peak drug concentration (Cmax), the area under the concentration-time curve (AUC), and, consequently, the trough concentration on the bactericidal effects of gentamicin against Enterobacter cloacae (MIC, 0.5 mg/liter) by simulating bolus versus infusion administration and bolus dosing with altered drug clearance. Bacteria in the lag...

The degree of penetration of newer quinolones into the pleural fluid has not been studied. The objective of the present study was to determine the degree to which moxifloxacin and levofloxacin penetrate into empyemic pleural fluid using a new rabbit model of empyema. An empyema was created via the intrapleural injection of turpentine (1 mL), followed 24 h later by instillation of 2 mL (1 x 10(1...