Stroke and Blood Coagulation • A study of the coagulation parameters of 87 normal controls (ages 50 to 80) were compared with those of 33 patients with thrombotic stroke and 55 patients with diabetes mellitus of the same age distribution. There were no significant differences when tested for the influence of sex or age. Twenty-seven tests of clotting were done on each specimen, a total of 4,725...

Administration of vitamin K-antagonists induces the appearance of abnormal clotting factors in the blood (man, cow) or in the l iver (rat). These abnormal clotting factors (descarboxyfactors) contain glutanfc acid (G1u) residues instead of the 7-carboxyglutamic acid (Gia) residues, which occur in normal clotting factors [1]. In human and bovine plasma -90% of the abnormal proteins consists of d...

The automated-activated coagulation time, manual-activated coagulation time and the activated partial thromboplastin time were compared to the whole blood clotting time in the measurement of hypocoagulation of heparinized blood. The normal ranges and degree of reproducibility were determined for each clotting assay. Each method was examined for its sensitivity to various concentrations of hepar...

'LFulbright Research Scholar, Department of Medicine, Oslo University, 1953-1954. 2 Present Address: Hematology Section, Veterans Administration Hospital, Long Beach, California. There is no standard nomenclature for the newer clotting factors. The following terms are used in this paper. Blood thromboplastin is used in its classic meaning of an activity which arises during clotting and which is...

A total of 230 cultures of fungi and 43 cultures of bacteria, isolated from such sources as soil, butter, and milk, were screened for their milk-clotting activity. The fungi were cultivated on semisolid media, and the bacteria were grown in milk media in shake culture. Phytic acid, added as calcium phytate, was found to stimulate production of the enzyme in most of the bacterial isolates. Prote...

DESPITE the large number of researches which have been made on blood coagulation, no single one of the many theories advanced satisfies the criterion of a tenable hypothesis in which all known facts should be correlated. A better understanding of the fluidity and clotting of blood should lead to important results. On the practical side, we may hope for the elucidation of thrombosis—the formatio...

Inherited diseases might be treated by introducing normal genes into a patient’s somatic tissues to correct the genetic defects. In the case of hemophilia resulting from a missing clotting factor. the required gene could be introduced into any cell as long as active factor reached the circulation. We previously showed that retroviral vectors can efficiently transfer genes into normal skin fibro...

The role of disseminated intravascular clotting (DIC) in the pathogenesis of the bleeding diathesis kwashiorkor was investigated in 22 patients. According to the severity of the clinical and haematological findings, two grades of DIC were observed. A severe grade of DIC was shown in 6 cases (5 fatal) presenting with thrombocytopenia, hypofibinogenaemia, and multiple coagulation defects, and wi...