Tetanus is a disease caused by tetanus toxin, a potent inhibitor for the release of inhibitory neurotransmitter in the central nervous system that causes spastic paralysis. Fragment C (52 kD) of this toxin is responsible for binding to the neuronal membrane. For this reason, and also its non toxigenic and immunogenic nature, this fragment might be ideal for new vaccine development. Presently, w...

Tetanus is a neurologic disorder caused by tetanospasmin, a protein toxin elaborated by Clostridium tetani. Cephalic tetanus is a localized form of the disease causing trismus and dysfunction of cranial nerves. We report the case of a man who presented with facial trauma, complete ophthalmoplegia, exophthalmos, areactive mydriasis, and periorbital hematoma. An orbital CT revealed air bubbles in...

At the threshold concentration (1-10 pmol l(-1)), the neuropeptide hormones proctolin (PR) and the FLRFamide-like peptide (FLP) F(2) cause an increase in amplitude of electrically evoked contractions (each contraction is a brief tetanus) of lobster heart ostial muscle. At higher concentrations each peptide also induces an increase in tonus (contracture). The PR-induced contracture and augmentat...

The crystal structure of Clostridium acidi-urici ferredoxin has been determined using multiple wavelength anomalous diffraction (MAD) techniques at 5.0-A resolution. The electron density map shows striking similarity to a map of Peptococcus aerogenes ferredoxin computed at the same resolution from the atomic coordinates reported by Adman et al. (Adman, E. T., Sieker, L. C., and Jensen, L. H. (1...

Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here systematically assessed anaerobic bacteria for their capacity to grow expansively within avascular compartments of transplanted tumors. Among 26 different strains tested, one (Clostridium novyi) appeared particul...

Latar belakang: Program imunisasi merupakan salah satu program penting di sektor kesehatan. ini bertujuan untuk menurunkan angka kesakitan, kecacatan dan kematian dari penyakit-penyakit terutama penyakit tetanus. Tetanus suatu toksemia akut yang disebabkan oleh neurotoksin dihasilkan Clostridium tetani ditandai dengan spasme otot periodik berat. biasanya menimbulkan paralitik spastik tetanospas...

Resumo O tétano é uma doença grave e rara em pequenos animais, de caráter agudo mediada pela ação da neurotoxina tetanospasmina, proveniente do bacilo Clostridium tetani. Neste relato descreve-se um caso canino, com ênfase seus aspectos clínicos terapêuticos, além sua recuperação clínica. Foi atendido no Hospital Veterinário Universidade Passo Fundo, fêmea, raça Pitbull, cinco meses, status epi...

Organisms regulate gene expression in response to the environment to coordinate metabolic reactions. Clostridium thermocellum expresses enzymes for both lignocellulose solubilization and its fermentation to produce ethanol. One LacI regulator termed GlyR3 in C. thermocellum ATCC 27405 was previously identified as a repressor of neighboring genes with repression relieved by laminaribiose (a β-1,...

4. World Health Organization. Current recommendations for treatment of tetanus during humanitarian emergencies [cited 2012 Jan 15]. http://whqlibdoc.who.int/hq/2010/WHO_HSE_GAR_DCE_ 2010.2_eng.pdf 5. Digiacomo RF, Missakian EA. Tetanus in a free-ranging colony of Macaca mulatta: a clinical and epizootiologic study. Lab Anim Sci. 1972;22:378–83. 6. Rawlins GR, Kessler MJ. A fi ve-year study of t...

A procedure for the isolation of pure tetanus toxin in a lethal monomeric form was developed based on the extraction of whole cells and chromatographic techniques. A crude extract of toxin was obtained by hypertonic extraction of cells from a 72-hr culture of Clostridium tetani Massachusetts strain. The extract was precipitated with ammonium sulfate and further purified by sequential use of ion...