The combination of an amide containing a linear ligand (L1) and an organometallic molecular "clip" (clip-1) leads to the self-assembly of a Pt4 nanoscopic framework representing the first example of a Pt-based molecular rectangle (rectangle-1) incorporating amide functionality. A complementary approach was also followed to prepare a Pd(II)-based molecular rectangle (rectangle-2) by reaction of ...

The past decades have witnessed a surge of discoveries revealing RNA regulation as a central player in cellular processes. RNAs are regulated by RNAbinding proteins (RBPs) at all post-transcriptional stages, including splicing, transportation, stabilization and translation. Defects in the functions of these RBPs underlie a broad spectrum of human pathologies. Systematic identification of RBP fu...

Sea turtles are slow-maturing animals that are known to make long transoceanic migrations, even returning back to their natal beaches. However, until very recently, the only knowledge of these journeys was available through the tracking of flipper tags when mature females ventured onto land to nest. Conservation organizations and governments have been monitoring these species for a number of ye...

BACKGROUND To evaluate the effectiveness and safety of the DS Titanium Ligation Clip for appendicular stump closure in laparoscopic appendectomy. METHODS Overall, 502 patients undergoing laparoscopic appendectomy were recruited for this observational multicentre study in nine study centres between October 2011 and July 2013. The clip was finally applied in 390 patients. Primary outcome variab...

BACKGROUND AND STUDY AIMS The effectiveness of the prophylactic clip for the prevention of postpolypectomy bleeding in pedunculated colonic polyps has not been confirmed. The aim of this prospective, randomized study was to compare the efficacy of prophylactic clip and endoloop application in the prevention of postpolypectomy bleeding in large pedunculated polyps. PATIENTS AND METHODS A total...

Class II invariant chain peptide (CLIP) expression has been demonstrated to play a pivotal role in the regulation of B cell function after nonspecific polyclonal expansion. Several studies have shown vitamin D3 helps regulate the immune response. We hypothesized that activated vitamin D3 suppresses CLIP expression on activated B-cells after nonspecific activation or priming of C57BL/6 mice with...

Effective antitumor responses need the activation of CD4+ T cells. MHC class II antigen presentation requires the release of class II-associated invariant chain peptide (CLIP) from the antigen-binding site. In antigen-presenting cells, human leukocyte antigen DM (HLA-DM; abbreviated DM in this article) catalyzes CLIP dissociation. In B cells, HLA-DO (DO) down-modulates DM function. Cell surface...

References 1 Kesby GJ, Korda AR. Migration of a Filshie clip into the urinary bladder seven years after laparoscopic sterilisation. Br J Obstet Gynaecol 1997; 104: 379–382. 2 Filshie GM, Casey D, Pogmore JR, Dutton AG, Symonds EM, Peake AB. The titanium/silicon rubber clip for female sterilization. Br J Obstet Gynaecol 1981; 88: 655–656. 3 Graf AH, Staudach A, Steiner H, Spitzer D, Martin A. An...

Encoding guidelines and treatment protocols in formal and computer-executable form is not a trivial task and requires the collaboration between clinicians and knowledge engineers. In this paper, we describe CliP-MoKi, a Semantic Media Wiki (SMW)-based tool for the collaborative encoding in a distributed environment of cancer treatment protocols in Asbru. CliP-MoKi exploits the great flexibility...

IMPORTANCE Nodal ultrasonography with needle biopsy of abnormal lymph nodes helps to define the extent of breast cancer before neoadjuvant chemotherapy. A clip can be placed to designate lymph nodes with documented metastases. Targeted axillary dissection or selective removal of lymph nodes known to contain metastases (clip-containing nodes) as well as sentinel lymph nodes (SLNs) may provide mo...