Gentlemen, to open an address such as this with an expression of the honour which the speaker feels has been thrust upon him is, I know, so usual as to be almost trite; but I hope that the importance of the occasion may be my earnest that I speak both heartily and truly when I say, that I feel it a great and pleasant honour being asked to addres8 you. For a meeting such as this denoting, as it ...

Provides a review of laboratory and performance-based assessment techniques that have been used in research with children who have severe conduct problems. Many of these techniques have proven useful for monitoring the effects of interventions, which seems to be their most immediate clinical use. With further development, several of these techniques have the potential for assessing clinically i...

Laboratory testing is a highly complex process and, although laboratory services are relatively safe, they are not as safe as they could or should be. Clinical laboratories have long focused their attention on quality control methods and quality assessment programs dealing with analytical aspects of testing. However, a growing body of evidence accumulated in recent decades demonstrates that qua...

Automated spectrophotometric, electrochemical, and immunochemical analyses have become the mainstays of clinical chemistry and toxicology laboratory services, but their scope is limited. A wide array of clinically relevant analytes demand more sophisticated analytical techniques to provide sensitive and specific assays for diagnostic purposes. Gas chromatography (GC) and mass spectrometry (MS) ...

CDC has released updated guidance online for U.S. laboratory testing for Zika virus infection. The guidance is available at https://www.cdc.gov/zika/laboratories/lab-guidance.html. Frequently asked questions are addressed at https://www.cdc.gov/zika/laboratories/lab-guidance-faq.html. This guidance updates recommendations for testing of specimens by U.S. laboratories for possible Zika virus inf...

The evolution of cholesterol testing provides an example of a systematic approach that developed to relate the medical use of a laboratory test with the analytical performance requirements for that test. Laboratories today have the capability to perform cholesterol testing with the accuracy and precision necessary to meet medical needs. This statement can be made because (a) a standard diagnost...