Transcutaneous partial oxygen tension (tc pO2) and skin blood flow (via heat clearance) were measured noninvasively in 22 male subjects who performed stress-inducing tasks (i.e. hand-grip exercise, cold pressor test, breath holding, hyperventilation and mirror-tracing). An analysis of variance and covariance was conducted for tc pO2, heat clearance, heart rate, respiration rate, finger pulse vo...

To characterize the rate and regulation of alveolar fluid clearance in the uninjured human lung, pulmonary edema fluid and plasma were sampled within the first 4 h after tracheal intubation in 65 mechanically ventilated patients with severe hydrostatic pulmonary edema. Alveolar fluid clearance was calculated from the change in pulmonary edema fluid protein concentration over time. Overall, 75% ...

BACKGROUND AND OBJECTIVES This study aimed at evaluating acute radiological contrast effects in fluid restriction situations, observing renal and cardiovascular effects after intra-arterial injection of high osmolarity radiological contrast. METHODS Participated in this study 16 dogs anesthetized with sodium thiopental (15 mg.kg-1) and fentanyl (0.03 mL.kg-1), followed by continuous infusion ...

BACKGROUND Significant under-prediction of in vivo clearance in rat was observed for a potent p21-activated kinase (PAK1) inhibitor, GNE1. OBJECTIVE Rate-determining (rapid uptake) and rate-limiting (slow excretion) steps in systemic clearance and elimination of GNE1, respectively, were evaluated to better understand the cause of the in vitro-in vivo (IVIV) disconnect. METHODS A series of i...

Measurement of the rate of clearance of 133Xenon from the brain after injection of this radioisotope into the internal carotid artery has become an accepted method for estimating cerebral blood flow (H0edt-Rasmussen, 1965, 1967; Ingvar, Cronqvist, Ekberg, Risberg, and H0edt-Rasmussen, 1965). Resolution of the clearance curves into two components, fast and slow, may be carried out (H0edtRasmusse...

Circadian and meal effects on nicotine kinetics determine in part blood nicotine concentrations and in doing so may influence cigarette smoking behavior throughout the day. We have shown previously that nicotine clearance varies by approximately 17% (from peak to through) due to diurnal factors throughout the day and that meals increase nicotine clearance by about 42%. Until now pharmacokinetic...

This study analyzed the engine operating condition curve of corn kernel harvester. Field experiments identified feed rate, concave clearance, and cylinder speed as main factors affecting quality efficiency. A ternary quadratic regression orthogonal center-of-rotation combined optimization test method was used to determine speed, clearance influencing factors, variation crushing impurity loss ra...

PURPOSE The spontaneous seroconversion rate of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) virus infection in children is lower than that in adults. However, few studies have investigated the rate of transition from the immune-tolerant to the early immune-clearance phase in children. METHODS From February 2000 to August 2011, we enrolled 133 children aged <18 years who ha...

Abnormal accumulation of disease proteins in the central nervous system is a neuropathological feature neurodegenerative disorders. Recently, growing body evidence has supported role disruption sleep-wake cycle development, pathological changes and abnormal protein diseases, especially Alzheimer’s Parkinson’s disease. Sleep deprivation promotes proteins. Interestingly, amyloid-? (A?) daily osci...

BACKGROUND Moderate alcohol consumption is widely recognized as beneficial in the prevention of cardiovascular disease, yet the renal effects of alcohol intake are still controversial. The present study is designed to investigate the influence of alcohol consumption on calculated creatinine clearance rate (CCr) and glomerular filtration rate (GFR) in a Southern Taiwan Pai-Wan aboriginal communi...