نتایج جستجو برای: cladribine
تعداد نتایج: 689 فیلتر نتایج به سال:
CEM-ARAC leukemia cells with resistance to cytarabine were shown to lack equilibrative transporter (hENT1) expression and activity. Stable transfer of hCNT2 cDNA into CEM-ARAC enabled Na(+)-dependent transport of purine and pyrimidine nucleoside analogs and provided a unique in vitro model for studying hCNT2. Analysis of [(3)H]uridine inhibitory activity by test substances in hCNT2 transfectant...
BACKGROUND The heterogeneity of chronic lymphocytic leukemia (CLL) is thought to be due to differences in the expression of factors that regulate apoptosis and cell cycle, giving rise to diverse apoptotic disturbances and tumor properties. Therefore, the primary goal in CLL treatment is to overcome resistance to apoptosis and efficiently trigger this process in leukemic cells. METHODS Mononuc...
INTERACTION OF CLADRIBINE AND FLUDARABINE WITH GENETIC VARIANTS IN THE CONCENTRATIVE NUCLEOSIDE TRANSPORTER, CNT3. I. Badagnani, PharmD, and K. M. Giacomini, PhD, Department of Biopharmaceutical Sciences, University of California, San Francisco, CA. The concentrative nucleoside transporter, CNT3 (SLC28A3), mediates the intracellular uptake of the anti-cancer nucleoside analogs, cladribine and f...
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