There are a wide variety of dressing techniques available for the management of both acute and chronic wounds. The primary objective in both the cases is to achieve a healed wound. An ideal dressing material should accelerate wound healing and reduce loss of necessary fluids from the wound, and also help minimize pain and infection. The present trend is to promote the concept of moist wound hea...

Wound healing is a complex biological process that is generally composed of four phases: hemostasis, inflammation, proliferation, and remodeling. The proliferation phase is crucial for effective healing compared to other phases. Many critical events occur during this phase, i.e., migration of fibroblasts, re-epithelialization, angiogenesis and wound contraction. Chronic wounds are common and ar...

Successful diagnosis and treatment of patients with chronic wounds involve holistic care and a team approach. The integration of the work of an interdisciplinary care team that includes doctors, nurses, and allied health professionals with the patient, family, significant others, and caregivers offers an optimal formula for achieving wound resolution. Such an approach challenges practitioners a...

Wound care is a critical aspect of healthcare that involves treating and managing various types wounds, typically caused by injuries, surgery, or chronic diseases such as diabetes. Chronic wounds can be particularly challenging to manage often require 3 6 months long-term care. In few instances, healing durations are highly unpredictable vary depending on the severity wound, patient’s overall h...

Background: The application of mesenchymal stem cells in the healing of chronic wounds is one of the most challenging issues in cell therapy. The present study investigated the efficacy of intradermal injection of umbilical cord Wharton's Jelly-derived mesenchymal stem cells in diabetic wound healing using ultrasound imaging in an animal model. Methods: During this experimental laboratory stud...

Diabetes Mellitus Type II (DM2) is a growing international health concern with no end in sight. Complications of DM2 involve a myriad of comorbidities including the serious complications of poor wound healing, chronic ulceration, and resultant limb amputation. In skin wound healing, which has definite, orderly phases, diabetes leads to improper function at all stages. While the etiology of chro...

The ability to measure objectively wound healing is important for an effective wound management. Describing wound tissues in terms of percentages of each tissue colour is an approved clinical method of wound assessment. Wound healing is indicated by the growth of the red granulation tissue, which is rich in small blood capillaries that contain haemoglobin pigment reflecting the red colour of th...

BACKGROUND Bacterial colonization is hypothesized to play a pathogenic role in the non-healing state of chronic wounds. We characterized wound bacteria from a cohort of chronic wound patients using a 16S rRNA gene-based pyrosequencing approach and assessed the impact of diabetes and antibiotics on chronic wound microbiota. METHODOLOGY/PRINCIPAL FINDINGS We prospectively enrolled 24 patients a...

Recessive dystrophic epidermolysis bullosa is a severe genetic blistering skin condition resulting in chronic wounds. Nonhealing wounds were treated over 8 weeks using a reconstituted natural purified type I collagen skin substitute. Chronic wounds were defined as nonhealing wounds present for longer than 6 months. For each patient, two chronic wounds were identified and randomized into a contr...