Abstract Myeloid‐derived suppressor cells (MDSCs) refer to a group of immature myeloid with potent immunosuppressive capacity upon activation by pathological conditions. Because their ability, MDSCs have garnered extensive attention in the past few years fields oncology, infection, chronic inflammation and autoimmune diseases. Research on liver diseases has gradually increased, potential therap...

BACKGROUND It is a common clinical impression that fatigue is a frequent, and often debilitating, symptom in patients with chronic hepatitis C virus (HCV) infection. However, despite its obvious clinical importance, several aspects of fatigue, including its relationship with the underlying liver disease and the presence of psychologic disturbances, have not been well examined. GOALS The curre...

The seroepidemiology of Leptospira infection in patients suffering from liver disease has been poorly studied. Information about risk factors associated with infection in liver disease patients may help in the optimal planning of preventive measures. We sought to determine the association of Leptospira IgG seroprevalence and patients with liver diseases, and to determine the characteristics of ...

Fibrosis is part of the liver alterations in most chronic liver diseases (CLD). The pattern of fibrosis appears to be related to the pathogenetic mechanism of disease, explaining the relative diagnostic usefulness of various patterns of fibrosis for the liver histopathologist. Semiquantitative evaluation of fibrosis is also an important issue supporting the central role of the biopsy since this...

patients and methods in the double-blind placebo study, 33 obese children with nafld from 2008 to 2009 were included. lifestyle intervention (balanced calorie diet, 1300-1800 kcal/d and physical activity) was prescribed to all. the patients were concurrently randomized to receive vitamin e 400 mg/d (n = 17)] or placebo (n = 16). results at the end of six months of therapy there was significant ...

background: non-communicable diseases (ncds) annually kill over 35 million people worldwide. they are responsible for nearly two-thirds of the world's deaths. global health is facing a dramatic change. for the first time in human history, more than 80% of ncd-related deaths are in low- and middle-income countries. countries throughout the world are expected to lose significant amounts of nation...

conclusions functional renal impairment in diseases caused by hcv was more important than in diseases caused by hbv. the egfr was statistically lower in cirrhosis secondary to hcv than in hcv chronic hepatitis. results hbv chronic hepatitis, hcv chronic hepatitis, and cirrhosis secondary to these viruses were associated with a reduction of the gfr. the egfr was higher in patients with hbv chron...

Background: We conducted a study in order to determine the usefulness and diagnostic value of International Autoimmune Hepatitis Group (IAHG) score in non-autoimmune hepatitis (AIH) hepatic disorders as well as in AIH/ overlap syndromes and in cases with coexistence of AIH and other liver diseases. Methods: We applied the IAHG score in 423 patients with liver diseases excluding patients with AI...