Among chickens, meat-producing broiler strains are highly prone to develop severe pulmonary hypertension (PH) that is accompanied by endothelial dysfunction in the conduit extrapulmonary arteries. We hypothesized that exposure to chronic prenatal mild hypoxia would accelerate PH and endothelial dysfunction in smaller intrapulmonary arteries from broiler chickens. Fertilized broiler and layer (W...

The rheological properties of blood play an important role in the regulation of blood flow resistance in vessels. Numerous data show evidence for an impaired hemorheological characteristic in diabetes mellitus. The aim of this study was to investigate whether chronic severe leg ischaemia in diabetes may be associated with further hemorheologic impairment. To do this, whole blood viscosity, eryt...

To date, scientists have found that stress plays an important role in the formation of congenital malformations. It can be caused by influence negative environmental factors on pregnant woman or her own diseases. One consequences is hypoxia. acute and chronic, a impact both during pregnancy childbirth. They also distinguish local general The oxygen deficiency embryo fetus manifest itself utero ...

Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon are not well defined in vivo. We sought to determine how chronic hypoxia regulates molecular markers of protein synthesis and degradation in human skeletal muscle and whether these regulations were related to the regulation of the hypoxia-inducible factor (HIF) pathway. Eight young male subjects li...

• It is well known that hypoxia elicits an increase of pulmonary vascular resistance in man and in experimental animals.' Accumulated physiologic data suggest that hypoxia elicits vasoconstriction in either preor postcapillary vessels.' Anatomic studies have been inconclusive with reference to exact vasoconstrictor sites. It has been shown that chronic hypoxia leads to increased pulmonary arter...