Cardiovascular disease (CVD) is increasingly recognised as a complication of childhood chronic kidney disease (CKD) even in the absence of diabetes and hypertension. We hypothesized that an alteration in angiopoietin-1 and -2, growth factors which regulate endothelial and vascular function could be involved. We report that the endothelial survival factor, angiopoietin-1 is low in children with ...

BACKGROUND Atherosclerosis and vascular calcification are common in chronic haemodialysis (HD) patients, and usually progress with time. Whether the length of dialysis treatment in chronic HD patients is a significant independent risk factor of death is not clear. METHODS A cohort of chronic HD patients from the Okinawa Dialysis Study, n=1243 (720 men, 523 women), was followed from January 19...

BACKGROUND Beta-blockers may be cardioprotective in patients receiving chronic dialysis. We examined cardiovascular outcomes among incident dialysis patients receiving beta-blocker therapy. METHODS We conducted a retrospective cohort study employing linked healthcare databases in Ontario, Canada. We studied all consecutive chronic dialysis patients aged≥66 years who initiated dialysis between...

The annual mortality from cardiovascular disease in dialysis patients is substantially higher than in the general population (Figure 1) (1). The 5-yr survival of men .64 yr old starting dialysis is worse than that of men with colon cancer and prostate cancer (2). The 5-yr survival of women .64 yr old starting dialysis is worse than that of women with breast cancer and colon cancer (2). About ha...

AIM To assess the effectiveness of a decision support intervention using a pragmatic single blind Randomized Controlled Trial. BACKGROUND Worldwide the proportion of older people (aged 65 years and over) is rising. This population is known to have a higher prevalence of chronic diseases including chronic kidney disease. The resultant effect of the changing health landscape is seen in the incr...

RRT irrespective of the primary renal diagnosis and of the apparent duration of the diabetic disease. Conclusions Available data suggest that a proportion of RRT patients develop diabetes after renal treatment is started. The pathogenesis of the disease is multifactor-ial. In any case diabetes has a strong impact on survival. I hope that this editorial comment may motivate other nephrologists t...

BACKGROUND/AIMS Cognitive impairment and abnormal structural neuroimaging is common in chronic kidney disease patients. We aimed to explore its association with dialysis modality and the relationship between cognitive impairment and abnormal structural neuroimaging. METHODS Sixty peritoneal dialysis patients and 30 hemodialysis and 30 non-dialyzed stage 3-5 chronic kidney disease patients wit...

Chronic kidney disease—mineral and bone disorder (CKD-MBD) is a systemic that increases the risk of morbidity mortality in dialysis patients. CKD-MBD highly prevalent patients, appropriate treatment important for improving their outcomes. Inorganic phosphate, fibroblast growth factor 23, parathyroid hormone, calciprotein particles are markers critical components effectors CKD-MBD, higher circul...

An 81-year-old Caucasian male with stage 4 chronic kidney disease (CKD) successfully avoided dialysis through specific lifestyle modifications. By following a strict vegetarian diet, avoiding animal proteins entirely, and adhering to medication regimen, there was an immediate improvement in his function. Three years into newly adopted lifestyle, he remains off dialysis. This case report discuss...