I read in your Journal, with great interest, the paper by Veiga and coworkers about two cases of clear cell acanthomas located in the nipple area, with histological and immunohistochemical studies. They claim in the discussion, that only five cases had been previously described in the English literature and all affecting Korean women. Four of these cases mimicked chronic eczema. Two new cases w...

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative s...

Atopic dermatitis is a chronic inflammatory skin disease that affects large number of pediatric patients between 2 and 17 years age. Typical symptoms include intense itching, erythema, scaling the skin. has been found to be associated with decreased quality life for their families. Diagnosis made by clinical evaluation differential diagnosis other dermatologic diseases. Treatment based on sever...

Background. Atopic dermatitis is a chronic multifactorial dermatosis with complex pathophysiological basis. One of the poorly studied links in pathogenesis disease endothelin-1. Its main biological effects include pronounced vasoconstriction blood vessels.
 Aim. To study role endothelin-1 and its autoantibodies atopic dermatitis.
 Materials methods. The included 40 patients common lim...

The new scoring system for assessment of the extent and severity of skin inflammation index in atopic dermatitis patients, W-AZS, is presented. The system provides detailed assessment of both subjective and objective signs and symptoms of atopic dermatitis. With the use of W-AZS, acute and chronic skin manifestations of inflammatory process are appropriately evaluated and scored. It also enable...

BACKGROUND Atopic dermatitis often has an allergic component, and immunotherapy may therefore prove beneficial. OBJECTIVE To assess the effect of sublingual immunotherapy (SLIT) in children with atopic dermatitis. METHODS Children age 5 to 16 years with atopic dermatitis (Scoring Atopic Dermatitis [SCORAD] > 7) and sensitization to dust mites alone, without food allergy or chronic asthma, w...

Dermatitis is a commonly encountered skin inflammation with variable etiology and clinical presentation. Available treatment options for dermatitis management have a major drawback of failure in prevently high recurrence and chronic dermatosis are characterized by recurrent exacerbations and remissions. This study was planned to evaluate the clinical efficacy and shortand long-term safety of Pu...

BACKGROUND The literature has shown that the presence of emotional disturbances in caregivers of children with skin diseases affects the course and treatment of the disease. Anxiety and depression are among the most frequently reported psychiatric diagnoses related to this fact. OBJECTIVE To evaluate the presence of anxiety and depression in caregivers of pediatric patients with chronic skin ...