This multi-author book has an ambitious title that promises more than the book delivers. The title would lead one to assume that the monograph covers most aspects of the control of breathing and its abnormalities in disease states. Unfortunately, that is not the case, and the coverage is selective, both in the basic physiology and the pathophysiology of the control of breathing. On the other ha...

Chronic bronchial disease constitutes a significant, yet underdiagnosed, cause of both chronic cough, episodic as well as, acute-onset respiratory distress in the adult dog. Untreated, chronic bronchial disease is a debilitating, progressive respiratory syndrome that characteristically results in decreased exercise tolerance, inactivity, paroxysmal respiratory distress, airway collapse, and eve...

Gastro-oesophageal reflux (GOR) is an important cause of chronic cough. There has been a lack of placebo-controlled trials treating GOR related chronic cough with antireflux therapy. The aim of this study was to determine the efficacy of omeprazole on GOR related chronic cough. After excluding other common causes of cough, oesophageal pH monitoring was performed on 48 patients with chronic coug...

BACKGROUND Chronic cough is associated with increased sensitivity to inhaled capsaicin, and both tachykinins and their receptors play important roles in the cough reflex. However, associations between polymorphisms of the tachykinin receptor genes and cough sensitivity in patients with non-productive chronic cough have not been reported. METHODS Direct sequencing was used to identify single n...

Chronic cough is a common condition that presents to both primary and secondary care. Assessment and management are hampered by the absence of well-validated outcome measures. The present study comprises the validation of the Leicester Cough Monitor (LCM), an automated sound-based ambulatory cough monitor. Cough frequency was measured with the LCM and compared with coughs and other sounds count...

histopathology of chronic cough: a prospective, controlled, comparative study.Chest2006;130:362–70. 6 Chaudhuri R, McMahon AD, Thomson LJ, et al. Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. J Allergy Clin Immunol 2004;113:1063–70. 7 Birring SS, Parker D, Brightling CE, et al. Induced sputum inflammatory mediator concentrations in...

1 Palombini BC, Villanova CAC, Araujo E, et al. A pathogenic triad in chronic cough. Chest 1999; 116:279–284 2 Irwin RS, Corrao WM, Pratter RM. Chronic cough: the spectrum and frequency of causes, key components of diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis 1990; 141:640–647 3 Pratter MR, Bartter T, Akers S, et al. An algorithmic approach to chronic cough. Ann Int...

OBJECTIVES To review the literature on habit, tic, and psychogenic cough, and to make evidence-based recommendations regarding diagnosis and treatment. DESIGN/METHODOLOGY For data on adults, an Ovid MEDLINE literature review (through February 2005) was performed for all studies published in the English language, including case series and case reports, since 1966 using the medical subject head...

Cough is an important symptom of many respiratory disorders. We determined the frequency and diurnal variation of cough in normal subjects and in patients with asthma or with persistent cough of unknown cause. We used a portable, solid-state, multiple-channel recorder to record cough sounds over a 24 h period. The audio-signal was recorded from a unidirectional microphone strapped over the ches...

Cough is an important protective mechanism that clears foreign material from the airway and aids in immune defence. However, chronic excessive cough of various aetiologies is a common presentation to specialist respiratory clinics, and is reported as a troublesome symptom by a significant proportion of the population (Ford et al., 2006). In extreme situations chronic cough can persist for sever...