Dasatinib (DAS), a second-generation tyrosine kinase inhibitor, is highly effective in treating chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. However, its clinical use is limited due to serious adverse effects. DAS can disrupt endothelial barrier integrity and increase endothelial permeability which may cause peripheral edema and pleural effusion. A...

Salmonella enterica subspecies enterica serovar Typhi is a rod-shaped, Gram-negative, facultatively anaerobic bacterium. It belongs to the family Enterobacteriaceae in the class Gammaproteobacteria, and has the capability of residing in the human gallbladder by forming a biofilm and hence causing the person to become a typhoid carrier. Here we present the complete genome of Salmonella enterica ...

The first stage of these studies consisted in the development of antitumor drugs of the type of alkylating metabolites 1952-55 (5, 6, 13). These are metabolites or other natural or biologically active compounds which are combined with a cytotoxic group (e.g., the chloroethylamino group). Sarcolysin and dopan are representative of drugs of this type. In the former, the essential amino acid, phen...

The availability of CD4C/HIV(MutA) transgenic (Tg) mice expressing human immunodeficiency virus type 1 in immune cells and developing an AIDS-like disease has provided the opportunity to devise a model of mucosal candidiasis that closely mimics the clinical and pathologic features of candidal infection in human AIDS. After intraoral infection with Candida albicans, oral burdens were strikingly ...

A hepatitis B mass immunization program was launched in Taiwan in July 1984, beginning with newborns of hepatitis B carrier mothers for the first 2 years of the program, which was then extended to all newborns. Seroepidemiology was studied in 3 cohorts at age 6 years. Each cohort consisted of 1500 children proportionally and randomly sampled from those entering elementary school in 1989, 1991, ...

The first stage of these studies consisted in the development of antitumor drugs of the type of alkylating metabolites 1952-55 (5, 6, 13). These are metabolites or other natural or biologically active compounds which are combined with a cytotoxic group (e.g., the chloroethylamino group). Sarcolysin and dopan are representative of drugs of this type. In the former, the essential amino acid, phen...

Crusted scabies, formerly known as Norwegian scabies is uncommon presentation of that may occur in the association with an immunosuppressive status. The article aims to present a case report which male patient HTLV-1 carrier status admitted for investigation eczematous and crusted chronic skin lesions submitted dermatologic evaluation biopsy considering hypothesis cutaneous form lymphoma associ...

Circulating microRNAs have been widely recognized as a novel category of biomarker in a variety of physiological and pathological conditions. Other reports revealed that fragments of organ specific messenger RNAs are also detectable in serum/plasma and can be utilized as sensitive indicators of liver pathology and cancer. In order to assess the sensitivity and reliability of these two class of ...