Chromosomal abnormalities represent a significant genetic cause of male infertility because they impair spermatogenesis. The objective the current study was to determine prevalence and distribution chromosomal in Greek men with infertility. Four hundred eighty-eight infertile (27 azoospermic, 168 oligospermia -98 mild, 57 moderate, 13 severe- 293 normospermia) undergoing In <em>Vitro <...

OBJECTIVE Chromosomal aberrations are common causes of multiple anomaly syndromes. Recurrent chromosomal aberrations have been identified by conventional cytogenetic methods used widely as one of the most important clinical diagnostic techniques. MATERIALS AND METHODS In this retrospective study, the incidences of chromosomal aberrations were evaluated in a six year period from 2005 to 2011 i...

It is widely accepted that both large-scale chromosomal abnormalities and mutation of specific genes, such as APC, K-ras, and/or p53, occur in the majority of colorectal adenocarcinomas. Whether or not a relationship exists between these different forms of genetic abnormalities was previously unknown. Using comparative genomic hybridization and mutational analysis of APC, K-ras, and p53 to eval...

Blood samples were spiked with Na-24 to study the separate effect of this nuclide on the incidence of chromosomal aberrations in neutron irradiated blood samples. A delay of 96 h was allowed before cultivation, so the results of chromosomal aberration analysis could be compared with the results obtained by direct irradiation of blood samples with U-235 fission neutrons [7]. The absorbed dose wa...

Epilepsy is among the most common findings associated with chromosome aberrations, particularly those involving autosomal chromosome imbalances. Most chromosome aberrations can be associated with different seizure types, but there are a few aberrations featuring specific seizure and electroencephalographic (EEG) patterns. The analysis of electro-clinical patterns associated with chromosomal abe...

We have developed a model that can simulate the yield of radiation-induced chromosomal aberrations (CAs) and unrejoined chromosome breaks in normal and repair-deficient cells. The model predicts the kinetics of chromosomal aberration formation after exposure in the G₀/G₁ phase of the cell cycle to either low- or high-LET radiation. A previously formulated model based on a stochastic Monte Carlo...

The aim of study is to analyze the clinical and cytogenetic investigation on patients with PDD, MR and BAP from South Indian population. Cytogenetic analysis of 11 patients with PDD, 3 patients with BAP and 12 patients with MR were carried out by using human leukocyte culturing method and clinical analysis were carried out for all the cases with the help of physicians. A significantly higher nu...

purpose: to verify the myofibroblastic origin of spindle cells by immunohistochemistry in idiopathic inflammatory pseudotumor (ipt) of the orbit. methods: we reviewed a series of 32 orbital ipts for expression smooth muscle actin (sma), vimentin, desmin and anaplastic lymphokinase (alk). results: the study was performed on histologic samples of 33 patients with a diagnosis of orbital ipt. the l...

the patients evaluated in this study were classified into three groups of severe, moderate, and mild according to the severity of exposure to sulfur mustard. we evaluated the immunological and cytogenetical status of the patients after eight years of their exposure to sulfur mustard. the investigations revealed that the number of neutrophils, lymphocytes and monocytes in the patients with sever...