Treatment with colchicine or x-radiation of a human embryonal carcinoma of testicular origin, which has secreted a chorionic gonadotropin-like hormone in ~0 per cent of heterografted hosts, resulted in a 2 89 times increase in the incidence of chorionic gonadotropin-secreting tumors as determined in oophorectomized and hypophysectomized animals. Lines developed from three of the tumors treated ...

The luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is essential for fertility in men and women. LHCGR binds luteinizing hormone (LH) as well as the highly homologous chorionic gonadotropin. Signaling from LHCGR is required for steroidogenesis and gametogenesis in males and females and for sexual differentiation in the male. The importance of LHCGR in reproductive physiology is unde...

3A2 is an antibody raised against human chorionic gonadotropin and recognizes a linear epitope on the C-terminal peptide of the human chorionic gonadotropin beta-subunit. Its three-dimensional structure has been determined to 2-A resolution using molecular replacement and refined to a conventional R-factor of 18.2%. The protein exhibits the typical immunoglobulin fold, and the model contains 94...

Placental polyp is a organized mass of retained bits of placental tissue following delivery, which is hyalinized during their prolonged retention. It is a rare entity, histologically composed of necrotic and hyalinized chorionic villi. These placental masses present within days to weeks following an abortion or delivery of a term placenta. The usual clinical presentations are abnormal uterine b...

The carbohydrate structure of the O-glycosidicallylinked oligosaccharide chains in P-subunit of human chorionic gonadotropin (hCG$) and their precise number and locations in the polypeptide chains have been determined. A homogeneous preparation of the O-glycosidic oligosaccharide was obtained from NaOH/ NaBH,-treated human chorionic gonadotropin by chromatography on Dowex 50 and Sephadex G-25 a...

Binding of human [(125)I]luteinizing hormone to homogenates of luteinized rat ovaries is dependent upon time, temperature, and pH and is saturable. Injection of human chorionic gonadotropin in vivo or addition of unlabeled human chorionic gonadotropin or human or ovine luteinizing hormone in vitro inhibits binding, whereas follicle stimulating hormone or prolactin is without effect. The dissoci...

A 22 years old lady was admitted because of progressive dyspnea, severe abdominal protrusion and lower extremity edema. She had undergone ovarian hyperstimulation for primary infertility by Clomiphen and Human chorionic gonadotropin for 3 months. Abdominopelvic ultrasonography revealed bilateral enlarged multi cystic ovaries and massive ascites. Transesophageal echocardiography revealed a large...

A case-control study was carried out on mothers of boys with undescended testis to investigate the hypotheses that raised maternal levels of oestrogen or reduced levels of human chorionic gonadotrophin in early pregnancy might be factors in the environment of the fetus associated with this condition. No significant difference in the levels of either of these hormones was found, though, if anyth...

Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are complex and a clear etiology for early activation is often not elucidated. Though collectively uncommon, the neoplastic and developmental causes of gonadotropin-dependent precocious puberty are very important to consider, as a del...

Discordance has been reported in human chorionic gonadotropin (hCG) concentrations measured by different immunoassay kits. We examined the results for 40 serum samples assayed with 10 different hCG immunoassay kits. Results varied considerably. Individual sample results varied by as much as 58-fold. Average results for different kits varied by as much as 1.4-fold for pregnancy (20 samples) and ...