A dynamic-contrast-enhanced magnetic resonance imaging (DCE-MRI) dataset consists of many imaging frames, often acquired both before and after contrast injection. Due to the length of time spent acquiring images, patient motion is likely and image re-alignment or registration is required before further analysis such as pharmacokinetic model fitting. Non-rigid image registration procedures may b...

Kinetic analysis with mathematical models has become increasingly important to quantify physiological parameters in computed tomography (CT), positron emission tomography (PET), and dynamic contrast-enhanced MRI (DCE-MRI). The modified Kety/Tofts model and the graphical (Patlak) model have been widely applied to DCE-MRI results in disease processes such as cancer, inflammation, and ischemia. In...

We present results from an extensive discrete choice experiment, which was conducted in three countries (Norway, Scotland, and England) with the aim of disclosing stated prescription behaviour in different decision making contexts and across different cost containment cultures. We show that GPs in all countries respond to information about societal costs, benefits and effectiveness, and that th...

The dechlorination processes of isomers trans and iso-dichloroethylene (iso-DCE) on Si(100)-2×1 were investigated from first principles, to ascertain the isomeric effect on the adjacent Si dimer di-dechlorination of DCE on Si(100)-2×1. By comparing the feasible adspecies and their reaction barriers between trans and cis-DCE on Si(100)-2×1, we found that the isomeric effect of trans-DCE is negli...

BACKGROUND For the first time in the history of HIV, new bio-medical interventions have been shown to be effective in preventing HIV transmission. For these new HIV prevention technologies (NPTs) to have an impact on the epidemic, they must be widely used. This study uses a discrete choice experiment (DCE) to: understand the relative strength of women's preferences for product characteristics, ...

PRS56 ASSeSSing CoPd PAtientS BuRden of diSeASe in A fold-in-fold-out diSCRete ChoiCe exPeRiment Goossens LM1, Stolk EA1, Donkers B1, Boland MR2, Rutten-van Mölken MP1 1Erasmus University Rotterdam, Rotterdam, The Netherlands, 2University of Oxford, Oxford, UK Objectives: The Assessment of Burden of COPD (ABC) tool evaluates and visualizes the health status of patients with chronic obstructive ...

PURPOSE To examine and compare patient and oncologist preferences for advanced melanoma treatment attributes and to document their trade-offs for benefits with risks. MATERIALS AND METHODS A discrete choice experiment (DCE) was conducted among advanced melanoma patients and oncologists. Qualitative pilot testing was used to inform the DCE design. A series of scenarios asked stakeholders to ch...

In this paper, we link findings from a demographically representative discrete choice experiment (DCE) in eight European countries on the adoption of smart thermostats with an agent-based model (ABM) methodologically consistent way. We employ ABM to simulate diffusion pattern until 2030 and examine effects subsidies recommendations by specific agents. Our highlight importance allowing for withi...