The effect of phenothiazines (trifluoperazine and chlorpromazine) on cholesteryl ester metabolism has been investigated in J 774 mouse monocyte-macrophages. The incorporation of oleic acid into cholesteryl ester and the activity of acylcoenzyme A: cholesterol-O-acyltransferase were strongly decreased in cells pretreated for 24 h with trifluoperazine or chlorpromazine. Furthermore, trifluoperazi...

PURPOSE: To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. METHODS: Sixteen Wistar rats - split in two groups - have been used: control group, receiving 3 mg/kg isotonic saline solution through caudal vein, and, the chlorpromazine group, receiving 3 mg/kg-IV of such medication. The nephrectomy of the left kidney lower third was...

Lung contains both Mg2+-dependent and Mg2+-independent phosphatidate phosphohydrolase activities. Addition of Triton X-100 (0.5%) or chlorpromazine (1 mM) leads to a marked increase in the total phosphatidate phosphohydrolase activity in rat lung microsomes (microsomal fractions), but a decrease in the Mg2+-dependent activity. These observations suggest that the Mg2+-independent activity is sti...

The surface activity of triflupromazine, chlorpromazine, promazine, promethazine, and chlorpromazine sulfoxide has been determined at the air-solution interface by the drop-volume method to measure surface tension. Differences in the abilities of the various phenothiazines employed to affect surface pressure development seem correlated with their relative nonpolarities. Anionic buffer ingredien...

Priapism is a prolonged and usually painful erection which is not associated with the sexual desire. It is an uncommon urologic emergency with variety of known etiologies such as the use of psychotropic medications. Priapism under concurrent treatment with chlorpromazine and risperidone has not been reported so far. Herein, a psychotic patient who developed priapism during chlorpromazine and ri...

Forty-four hospitalized schizophrenic patients, 22 in each of two groups, were treated for a period of 6 weeks with either EGT-GPZ combination or CPZ alone. Ratings on RP scale (Rockland and Pollin, 1S65) showed that the KGT-receiving group was significantly better en several measure at second week and also had an earlier onset of beneficial response on "Affect and Mood." However, at the end of...