Enantiomeric-enriched ferrocene-modified pyrazoles were synthesized via the reaction of the ferrocene alcohol, (S)-FcCH(OH)CH₃ (Fc = ferrocenyl), with various pyrazoles in acidic conditions at room temperature within several minutes. X-ray structural data for racemic (R,S)-1N-(3,5-dimethyl pyrazolyl)ethyl ferrocene (1) and its (S)-enantiomer (S)-1 were determined. A series of racemic pyrazolyla...

A commercially available machine induction tool was used in an attempt to automate the acquisition of the knowledge needed for an expert system for enan tioseparations by High Performance Liquid Chromatography using Pirkle type chi ral stationary phases CSPs Various rule sets were induced that recommended particular CSP chiral selectors based on the structural features of an enantiomer pair The...

Várias fases estacionárias baseadas em derivados de polissacarídeos e proteínas foram avaliadas para a resolução de alguns fármacos quirais e seus metabólitos. As fases estacionárias baseadas em polissacarídeos CHIRALCEL OD-H, CHIRALCEL OB-H, CHIRALCEL OJ, CHIRALPAK AD e CHIRALPAK AS foram avaliadas em condições de fase normal, usando hexano:2-propanol como fase móvel. Dietilamina ou ácido trif...

Novel cyclodextrin (CD) chiral stationary phases (CD-CSPs) with well-defined structure have been successfully synthesized by immobilization of mono/di(10-undecenoyl)-perphenylaminocarbonyl β-CD on the 3-mercaptopropyl functionalized silica gel via thiol-ene click chemistry. The phenyl carbamate groups on the rims of CD extended the cavity of CD-CSPs, which facilitated the formation of inclusion...

Synthetic dipeptides comprising mixtures of enantiomers, diastereomers, or sequential isomers were converted into their N-perfluoroacetyl dipeptide esters (perfluoroacetyl: trifluoroacetyl, pentafluoroacetyl, heptafluorobutyryl; ester: methyl, 1-propyl, 2-propyl, 2,2,2-trifluoroethyl) and analyzed by GC-MS on the chiral stationary phases Chirasil-L-Val and Lipodex-E using helium as carrier gas....

Hydrophilic interaction liquid chromatography (HILIC) today is a well-known and largely applied technique to analyse polar compounds such as pharmaceuticals, metabolites, proteins, peptides, amino acids, oligonucleotides, carbohydrates. Due the large number of stationary phases employed for HILIC applications, this review aims help reader in choosing proper phase, which often represents critica...