programmed cell death-1 (pd-1) and its ligands, pd-l1 and pd-l2, have been regarded as important immune system regulatory molecules. the aberrant expression of the molecules has been related to several autoimmune disorders. this study is aimed to assess the mrna expression level of pd-1, pd-l1, and pd-l2 molecules in the peripheral blood mononuclear mells (pbmcs) from multiple sclerosis (ms) pa...

The decay in the proficiency of native language (L1), known as first attrition, is one least understood phenomena associated with acquisition a second (L2). Indeed, exact cause for deterioration L1 performance, be that either interference from L2 or less frequent use L1, still remains elusive. In this opinion paper, we focus on largely understudied aspect attrition—namely, erosion orthographic ...

One of the basic questions of bilingual research is to what extent the bilingual’s two phonetic systems influence each other, a question that has occupied a prominent place in bilingual research almost from the outset of the field (see, for example, Weinreich, 1953). Recent studies in bilingual first language acquisition (BFLA) demonstrate that, at least in simultaneous bilingual acquisition, i...

PURPOSE To examine how age of immersion and proficiency in a 2nd language influence speech movement variability and speaking rate in both a 1st language and a 2nd language. METHOD A group of 21 Bengali-English bilingual speakers participated. Lip and jaw movements were recorded. For all 21 speakers, lip movement variability was assessed based on productions of Bengali (L1; 1st language) and E...

How Javanese (L1) learners of English (L2) produce durational features of vowels has received increasing interest in the study of second language acquisition because the vowel systems are very disparate. The present production experiment attempts to shed light on the interference by Javanese (L1) on English vowel production (L2). The results are discussed with respect to differences in the vowe...

Phonological alternations often serve to modify forms so that they respect a phonotactic restriction that applies across the words of language. Although it has long been assumed that an adequate theory of phonology should capture the connection between phonotactics and alternations, there is however, no psycholinguistic evidence that speakers actually do use a single mechanism for them both. In...

We propose a model of L2 phonological learning in which the acquisition of novel phonological category inventories proceeds not by mapping L2 inputs onto existing category inventories available in L1 and other already known languages, but rather through general categorization processes in which L1 and other language knowledge serves as an inductive bias. This approach views linguistic knowledge...

In the present study, we investigate how early and late L2 learners process L2 grammatical traits that are either present or absent in their native language (L1). Thirteen early (AoA = 4 years old) and 13 late (AoA = 18 years old) Spanish learners of Basque performed a grammatical judgment task on auditory Basque sentences while their event-related brain potentials (ERPs) were recorded. The sen...

The revised version of the Speech Learning Model (SLM-r) regards full-time equivalent (FTE), which involves amount L2 use during length residence (LOR) in an setting, as main factor speech acquisition. Previous studiesshowed that LOR has a significant effect on and L1 production perception but does not explain differences between populations (i.e., L1-Spanish L2-English vs. L1-English L2-Spanis...

To date, little research on pragmatic transfer has considered a multilingual situation where there is an interaction among three different languages spoken by one person. Of interest was whether pragmatic transfer of refusals among three languages spoken by the same person occurs from L1 and L2 to L3, L1 to L2 and then to L3 or from L1 and L1 (if there are more than one L1) to L2. This study ai...