It has been reported that nicotine shows some beneficial effects on Parkinson's disease. The purpose of the present study is to assess the therapeutic effects of nicotine chewing gum in patients with early-onset parkinsonism (EOP). The subjects were 8 patients with early-onset parkinsonism (male/female = 4/4, mean age; 51.3 years). Four out of 8 patients had a history of smoking (smokers). To e...

Based on these approaches, several types of medications, such as taste adulterants, stimulants, and tranquilizers have been tested as aids to smoking cessation (Kozlowski, in press; Raw 1978; Grabowski and Hall, this volume). Most of these medications have not been efficacious. Nicotine chewing gum is the exception (Hughes and Miller 1984). The major hypotheses to explain the efficacy of nicoti...

BACKGROUND Eructation is a physiologic event which allows gastric venting of swallowed air and most of the time is not perceived as a symptom. This is called gastric belching. Supragastric belching occurs when swallowed air does not reach the stomach and returns by mouth a short time after swallowing. This situation may cause discomfort, life limitations and problems in daily life. OBJECTIVE ...

Of 2110 adult cigarette smokers originally recruited to a study of the effect of antismoking advice in general practice, 429 who reported at follow up after one year that they had tried unsuccessfully to stop smoking were offered "a special antismoking chewing gum," either nicotine gum or a placebo gum, in a double blind study. Of 200 who were willing to try the gum, 101 were randomly allocated...

The aim of the present work is development and evaluation of Chlorpheniramine maleate medicated chewing gums and to study the influence of different plasticizers on physicochemical parameters and in vitro drug release profile. Chlorpheniramine maleate is used to relieve symptoms of allergy, hay fever and common cold. Prepared formulations are evaluated for thickness, hardness, weight variation,...

A 73-year-old woman who had undergone hysterectomy and radiotherapy 17 years previously for uterine leiomyosarcoma presented to the emergency department with newonset exertional shortness of breath of 4-days duration. On admission, she was dizzy and tachypneic at rest. Chest auscultation revealed an apical diastolic murmur, gallop, and bilateral rales, and bilateral pleural effusion and interst...

background: chewing gum is a habit practiced regularly by a relatively high proportion of individuals in many countries including india, and its use has increased within the last decade. the aim of this study was to determine the effects of sugar-free and sugar chewing gums on plaque deposition. materials and methods: the study is a double blind clinical trial involving 16 healthy volunteers (d...