The composition of the essential oils of Thymus pulegioides L. plants growing wild in Vilnius district (Lithuania) with "ester", lemon and carvacrol (phenol) odours were collected in one location and investigated by GC, GC/MS and IR-spectroscopy. The essential oils with lemon and carvacrol odour belong to corresponding known citral-geraniol and carvacrol chemotypes. The essential oil of plants ...

In Brazil, four populations of Lutzomyia longipalpis each producing different sex pheromones are recognised. It has been suggested that these chemotype populations represent true sibling species. In this study we present the results of an analysis, by coupled gas chromatography-mass spectrometry, of the pheromones of males L. longipalpis from two different municipalities of the state of São Pau...

Natural product (NP)-inspired design principles provide invaluable guidance for bioactive compound discovery. Pseudo-natural products (PNPs) are de-novo combinations of NP fragments to target biologically relevant chemical space not covered by NPs. We describe the and synthesis apoxidoles, a novel pseudo-NP class, whereby indole- tetrahydropyridine linked in monopodal connectivity found nature....

The taxonomic position of bacterial strain 141T, isolated from the mangrove rhizosphere, has been clarified by phenotypic, chemotaxonomic and phylogenetic studies. The strain possesses wall chemotype IV, MK-9(H2) as the predominant menaquinone, relatively long-chain mycolic acids (56-64) carbon atoms) and straight-chain saturated and monounsaturated fatty acids with a small amount of tuberculos...

The compound of essential oil of thyme which was morphologically similar to Thymus pubescens (Lamiaceae) grown at Azarbijan region, was different from pervious reporters. This secondary metabolite extracted from this plant is citronellol which is the main essential oil in the rosa family. These findings showed clear chemical polymorphism with the Th. pubescens taxon that might lead us to new sp...

Fused pyrimidine cores are privileged kinase scaffolds, yet few examples of the 2-amino-pyrido[3,4-d]pyrimidine chemotype have been disclosed in the context of kinase inhibitor programs. Furthermore, no general synthetic route has been reported to access 2-amino-pyrido[3,4-d]pyrimidine derivatives. Here we report a versatile and efficient chemical approach to this class of molecules. Our strate...

Soil microbiomes are a rich source of uncharacterized natural product biosynthetic gene clusters. Here we use short conserved biosynthetic gene sequences (natural product sequence tags) amplified from soil microbiomes as phylogenetic markers to correlate genotype to chemotype and target the discovery of novel bioactive pentangular polyphenols from the environment. The heterologous expression of...