chemotherapeutics

Stanleyson V. Hato Carl G. Figdor Susumu Takahashi Anja E. Pen Altuna Halilovic Kalijn F. Bol Angela Vasaturo Yukie Inoue Nienke de Haas Dagmar Verweij Carla M.L. Van Herpen Johannes H. Kaanders Johan H.J.M. van Krieken Hanneke W.M. Van Laarhoven Gerrit K.J. Hooijer Cornelis J.A. Punt Akira Asai I. Jolanda M. de Vries W. Joost Lesterhuis

Platinum-based chemotherapeutics are amongst the most powerful anti-cancer drugs. Although their exact mechanism of action is not well understood, it is thought to be mediated through covalent DNA binding. We investigated the effect of platinum-based chemotherapeutics on signaling through signal transducer and activator of transcription (STAT) proteins, which are involved in many oncogenic sign...

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Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012

Poulomi Sengupta Sudipta Basu Shivani Soni Ambarish Pandey Bhaskar Roy Michael S Oh Kenneth T Chin Abhimanyu S Paraskar Sasmit Sarangi Yamicia Connor Venkata S Sabbisetti Jawahar Kopparam Ashish Kulkarni Katherine Muto Chitra Amarasiriwardena Innocent Jayawardene Nicola Lupoli Daniela M Dinulescu Joseph V Bonventre Raghunath A Mashelkar Shiladitya Sengupta

Nanoscale drug delivery vehicles have been harnessed extensively as carriers for cancer chemotherapeutics. However, traditional pharmaceutical approaches for nanoformulation have been a challenge with molecules that exhibit incompatible physicochemical properties, such as platinum-based chemotherapeutics. Here we propose a paradigm based on rational design of active molecules that facilitate su...

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