Neutrophils, in cooperation with serum, are vital gatekeepers of a host's microbiome and frontline defenders against invading microbes. Yet because human neutrophils are not amenable to many biological techniques, the mechanisms governing their immunological functions remain poorly understood. We here combine state-of-the-art single-cell experiments with flow cytometry to examine how temperatur...

a case of palmoplantar hyperkeratosis with periodontosis and a history of recurrent severe pyoderma, pneumonia and multiple liver abscesses is described in a 12 year old girl. the patient demonstrated neutrophil dysfunction characterized by decreased random migration and chemotaxis and defective bactericidal activity. the exact immunopathological mechanism for susceptibility to infections in pa...

The role of the polymorphonuclear leukocyte (PMNL) as a primary protective cell in periodontal diseases has been well recognized. Functional abnormalities of PMNL chemotaxis have been implicated in the pathogenesis of some types of periodontitis. However, no consistent correlation with other PMNL functions has been reported. In the present study, phagocytosis and intracellular killing (oxidativ...

Background: Spermatozoa are able to sense an attractant molecule gradient and as a consequence, orient their movement towards the source of the attractant. This mechanism is known as sperm chemotaxis. In recent years, our laboratory contributed to the knowledge of several features of mammalian sperm chemotaxis. These include the size and physiological state of the chemotactic sperm population, ...

Research on the use of natural products to treat or prevent microbial invasion as alternatives to antibiotic use is growing. Polymorphonuclear leukocytes (PMNL) play a vital role with regard to the innate immune response that affects severity or duration of mastitis. To our knowledge, effect of cold-pressed terpeneless Valencia orange oil (TCO) on bovine PMNL function has not been elucidated. T...

background : acanthamoeba castellanii forms a resistant cyst that protects the para-site against the host’s immune response. acanthamoeba type-i metacaspase (acmcp) is a caspase-like protein that has been found to be expressed during the encysta-tions. dictyostelium discoideum is an organism closely related to acanthamoeba useful for studying the molecular function of this protozoan caspase-lik...