The presence of mast cell precursors in peripheral blood was examined. The beige C57BL/6 (bgj/bgj, Chediak-Higashi syndrome) mouse was parabiosed with the normal C57BL/6 mouse. Mast cells containing giant granules and originating in the beige partner appeared in the normal parabiont. A comparable proportion of normal-mouse-type mast cells developed in the beige parabiont as well. In spite of th...

Chediak et al. have reported that the titer of procoagulant antihemophilic factor (AHF:C; factor VIII:C) was significantly lower in obligate carriers of classic hemophilia who were daughters of affected men (paternal carriers) than in those whose fathers were normal by history (maternal carriers). In contrast, among 113 obligate carriers of hemophilia, no significant difference in procoagulant ...

sarcoma' refers to a miscellaneous group of undifferentiated tumours which may represent rather different malignant diseases. An increased incidence of lymphomas has also been observed in three congenital immunological deficiency diseases, namely, ataxia-telangiectasia, the Wiscott-Aldrich and Chediak-Higashi syndromes (Table 4). The evidence that malignant disease is increased in patients who ...