BACKGROUND The impact on patients suffering from chronic hand eczema (CHE) is enormous, as no licensed systemic treatment option with proven efficacy for CHE is available. Alitretinoin is a novel agent which showed high clinical efficacy in patients with severe, refractory CHE. We assessed the cost-effectiveness of alitretinoin for CHE patient treatment from a Swiss third party payer perspectiv...

BACKGROUND Hemangioendothelioma includes several types of vascular neoplasms , as well as both benign and malignant growth. CASE PRESENTATION This study evaluated a case of a 78-year-old female diagnosed with composite hemangioendothelioma (CHE). This patient had an 18-month history of painless inflammatory lesions and erythema on the left forehead and right upper eyelid. The clinical and pat...

Riassunto: La necessità di definire una misura di distanza tra Regole di Associazione, al fine di cogliere l’evoluzione temporale del fenomeno indagato, è di primaria importanza quando si dispone di basi di dati riferiti alle stesse variabili ma osservate in momenti di tempo successivi. L’obiettivo è quello di separare la naturale variabilità di un fenomeno nel tempo, da variazioni sistematiche...

English. In this paper we present an approach for joy, anger and neutral emotions detection based on an emerging sentiment language model. We propose an approach that can detect specific emotions from positive, neutral and negative sentiments and which favors the tweets that occur at recent sentiment spikes. Our results suggest that our approach can effectively detect joy, neutral and anger emo...

The chromosome-encoded class C β-lactamase CHE-1 produced by Enterobacter cloacae exhibits a lower sensitivity to avibactam than the P99 enzyme from which it is derived by a 6-residue deletion in the H-10 helix. In the present study, we investigated the sensitivity of CHE-1 to two other β-lactamase inhibitors: LK-157 (or Lek 157), a tricyclic β-lactam, and BAL29880, a bridged monobactam. With b...

BACKGROUND Accidental Injury is a traumatic event which not only influences physical, psychological, and social wellbeing of the households but also exerts extensive financial burden on them. Despite the devastating economic burden of injuries, in India, there is limited data available on injury epidemiology. This paper aims to, first, examine the socio-economic differentials in Out of Pocket E...

Dimethyl phosphorylated cholinesterase (ChE) is known to be more rapidly reactivated, spontaneously, and have a higher aging rate than diethyl phosphorylated ChE. This may result in differences in toxic signs and tolerance development after treatment of juvenile rats with methyl parathion (MPS), a dimethyl phosphorothionate, than after treatment with chlorpyrifos (CPS), a diethyl phosphorothion...

Questo paper presenta i primi esiti di un progetto di ricerca ancora in corso che mira a esplorare nuove forme di scrittura e rappresentazione etnografica. In particolare, la diffusione di tecnologie e pratiche di geo-tagging ha consentito di creare una piattaforma mediale plurale, in cui le tante soggettività che hanno osservato un complesso rituale funerario Bororo (nel Mato Grosso brasiliano...

I numeri primi sono spesso considerati enti “astratti” di interesse esclusivamente matematico. Scopo di questo saggio è la discussione di alcune proprietà dei numeri primi che hanno trovato importantissime applicazioni pratiche con l’avvento della crittografia a chiave pubblica negli anni ’70 e con la diffusione di Internet e del commercio elettronico di questi ultimi anni. Ci occuperemo di alc...