Theodore T. Allen, Shih-Hsien Tseng, Kerry Swanson, Mary Ann McClay Industrial & Systems Engineering, The Ohio State University, Columbus, Ohio President of St. Mary’s Janesville Hospital, Janesville, Wisconsin Process Excellence Black Belt, Sagata Ltd., Columbus, Ohio ABSTRACT This article describes the application of a five-phase Six Sigma define, measure, analyze, improve, and control (DMAIC...

Codon usage bias (CUB) is the well-known phenomenon that the frequency of synonymous codons is unequal. This is presumably the result of adaptive pressures favouring some codons over others. The underlying reason for this pressure is unknown, although a large number of possible driver mechanisms have been proposed. According to one hypothesis, the decoding time could be such a driver. A tacit a...

In many practical situations, multiple variables often need to be monitored simultaneously to ensure the process is in control. In this article, we develop a feasible multivariate monitoring procedure based on the general Multivariate Exponentially Weighted Moving Average (MEWMA) to monitor the multivariate count data. The multivariate count data is modeled using Poisson-Lognormal distribution ...

This paper proposes a distribution-free multivariate statistical process control (MSPC) chart to detect general distributional changes in multivariate process variables. The chart is deployed based on a multivariate goodness-of-fit test, which is extensible to high dimensional observations. The chart also employs data-dependent control limits, which are computed on line along with the charting ...