Sir, Sexually transmitted infections (STIs) are dynamic and show variable prevalence in different parts of the country depending on various epidemiological factors prevailing in that respective geographic area.[1] In the past, tropical infections such as chancroid, gonorrhea, and syphilis were considered as most important STIs in developing countries. However, with the effective management of b...

Survey of the literature shows that there is considerable confusion about genital granulomata. Von Haam (1940) classifies them as venereal and non-venereal. Venereal granulomata may be manifestations of syphilis, gonorrhoea, chancroid, lymphogranuloma venereum, or granuloma inguinale. Non-venereal granulomata may be tuberculous, fusospirochaetal, pyogenic, or saprophytic. The last group include...

Amoxycillin and clavulanic acid (Augmentin; Beecham Research Laboratories) was used to treat patients with bacteriologically proved chancroid in three different dose regimens. A single dose of Augmentin (amoxycillin 3 g, clavulanic acid 350 mg) was found to be ineffective. A similar dose repeated after 24 hours was equally ineffective, but a dose (amoxycillin 500 mg, clavulanic acid 250 mg) giv...

Recent studies undertaken in southern Africa and elsewhere indicate that many short or single dose treatments are available to treat chancroid. Erythromycin 500 mg three times a day for five days, ciprofloxacin 500 mg, sulphamethopyrazine 800 mg and trimethoprim 1000 mg or sulphametrole 3200 mg and trimethoprim 640 mg as single oral doses, or ceftriaxone 250 mg as a single intramuscular injecti...

One hundred and thirty seven patients presenting with genital ulcerations from which Haemophilus ducreyi was isolated were treated with erythromycin stearate 500 mg every six hours for seven days. Of these, 91 (66%) had associated inguinal lymphadenopathy. Only two of the 100 patients who returned after one week showed no clinical improvement. Despite decrease in size H ducreyi was reisolated f...

Physicians have long searched for an effective therapeutic agent against the unusually resistant diseases, granuloma inguinale and lymphogranuloma yenereum. Chancroid responds readily to antiseptic measures and the sulfonamide compounds. Syphilis is controlled by penicillin or arsenicals and bismuth compounds. Gonorrhea responds to the sulfonamides, penicillin or streptomycin. The discovery tha...