INTRODUCTION Interleukin-22 (IL-22) is a cytokine of IL-10 family with significant proliferative effect on different cell lines. Immunopathological role of IL-22 has been studied in rheumatoid arthritis (RA) and psoriasis. Here we are reporting the functional role of IL-22 in the inflammatory and proliferative cascades of psoriatic arthritis (PsA). METHOD From peripheral blood and synovial fl...

Switzerland), used for the treatment of chronic myeloid leukaemia, is able to inhibit the function of normal human T lym-phocytes in vitro [1]. In addition, this group demonstrated nilo-tinib inhibits T-cell receptor (TCR) activation and the phosphory-lation of signalling proteins involved in TCR activation. We have also investigated the effects of nilotinib on T cells and have expanded on the ...

We aimed to quantify the biological effects of an innovative Pickering emulsion coencapsulating immunosuppressive drug (e.g.cyclosporinA) in biodegradable and biocompatible PLGA nanoparticles, with anti-inflammatory (e.g.calcitriol) oil phase, on T-cells keratinocytes vitro a murine model psoriasis establish proof concept efficacy vivo. were isolated from healthy volunteer’ blood or skin explan...

To explore the role of interleukin-2 (IL-2) in T cell proliferation, and to circumvent the IL-2 deficiency autoimmune syndrome of conventional il2 gene deletion, mice were created to allow conditional il2 gene deletion when treated with the estrogen analog, tamoxifen (TAM) as adults. Splenocytes from four different mouse strains, C57Bl/6 wild type (WT), conventional IL-2(-/-), TAM-treated Cre r...

The cell cycle of antigen-specific T cells in vivo has been examined by using a few methods, all which possess some limitations. Bromodeoxyuridine (BrdU) marks that are or recently completed S-phase, and carboxyfluorescein succinimidyl ester (CFSE) detects daughter after division. However, these dyes do not allow identification the phase at time analysis. An alternative approach is to exploit K...

silybum marianum, is known to have anti-inflammatory, hepatoprotective and anticarciogenic effects. the aim of this study was to compare effects of silymarin, rapamycin and fk506 on proliferation and apoptosis of human t cells stimulated with con a. peripheral blood mononuclear cells (pbmc) were stimulated with concavalin a  ( con a) (5µg/ml) and then treated with different inhibitors (silymari...